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Dr Richard J Prankerd

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Senior Lecturer

BPharm University of Otago (NZ)
MPharm University of Otago (NZ)
PhD University of Otago (NZ)

Telephone: +61 3 9903 9003
Fax: +61 3 9903 9583
Email: richard.prankerd@pharm.monash.edu.au

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences

Research interests

  • Physical and pharmaceutical chemistry
  • Equilibrium and kinetic reactions for drugs in solution (with M McIntosh, D Morton)
  • Scanning and isothermal microcalorimetry
  • Analytical chromatography, thermal analysis and spectroscopy
  • Development of non-viral gene transfection agents (with C. Pouton, B. Boyd)
  • Formulation science

Education

  • Physical and pharmaceutical chemistry
  • Formulation chemistry
  • Drug stability

Representative publications

  1. Velkov T, Lim MLR, Capuano B, Prankerd RJ. A protocol for the combined sub-fractionation and delipidation of fatty acid binding proteins using hydrophobic interaction chromatography. J Chrom B. 2008; 867(2):238-46.
  2. Tarwadi, Jazayeri JA, Prankerd RJ, Pouton C. Preparation and in Vitro Evaluation of Novel Lipopeptide Transfection Agents for Efficient Gene Delivery. Bioconjugate Chemistry. 2008; 19:940-950.
  3. Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, Dong Y, Vennerstrom JL, Charman SA. Relationship between antimalarial activity and heme alkylation for spiro- and  dispiro-1,2,4-trioxolane  antimalarials. Antimicrob  Agents Chemother. 2008; 52:1291-1296.
  4. Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, McCullough KJ, Dong Y, Vennerstrom JL, Charman SA. Iron mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials. J Pharm Sci. 2007; 96:2945-2956.
  5. Prankerd RJ. Critical compilation of pKa values for pharmaceutical substances. Profiles of Drug Substances, Excipients and Related Methodology. H Brittain. 2007; 33:1-726. (the only pKa database in the literature in which each measured value has been scrutinized and the quality assessed)
  6. Perry CS, Charman SA, Prankerd RJ, Chiu FCK, Dong Y, Vennerstrom JL, Charman WN.  Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials. J Pharm Sci. 2006; 95:737-747.
  7. Charman SA, Perry CS, Chiu FCK, McIntosh KA, Prankerd RJ, Charman WN. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006; 95:256-267.
  8. Creek DJ, Chiu FCK, Prankerd RJ, Charman SA, Charman WN. Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt. J Pharm Sci. 2005; 94:1820-1829.
  9. Taillardat-Bertschinger R, Perry CS, Galland A, Prankerd RJ, Charman WN. Partitioning of halofantrine hydrochloride between water, micellar solutions and soybean oil: Effects on its apparent ionization constant. J Pharm Sci. 2003; 92(11):2217-28.
  10. Shackleford DM, Prankerd RJ, Scanlon MJ, Charman WN. Self-micellization of Gemfibrozil 1-O-b-Acyl Glucuronide in aqueous solution. Pharm Res. 2003; 20(3):465-470.
  11. Khoo S-M, Prankerd RJ, Edwards GA, Porter CJH, Charman WN. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after post-prandial administration to dogs. J Pharm Sci. 2002; 91:647-659. 
  12. Prankerd RJ, Jones RDM. The physicochemical compatibility of injectable propofol-thiopentone sodium admixtures. Am J Health-Syst Pharm 1996; 53:2606-10.
  13. Prankerd RJ, Stone HW, Sloan KB, Perrin JH. Degradation of aspartame in acidic aqueous media and its stabilization by complexation with cyclodextrin or modified cyclodextrins. Int J Pharm. 1992; 88:189-199.
  14. Prankerd RJ, Walters JM, Parnes JH. Kinetics for degradation of rifampicin, an azomethine-containing drug which exhibits reversible hydrolysis in acidic solutions. Int J Pharm. 1992; 78(1):59-67.
  15. Elsabee M, Prankerd RJ. Solid state properties of drugs. Part III. Differential scanning calorimetry of drugs existing as racemic solid solutions, racemic mixtures and racemic compounds. Int J Pharm. 1992; 86:221-230.
  16. Elsabee M, Prankerd RJ. Solid state properties of drugs. Part II. Peak shape analysis and deconvolution of overlapping endotherms in differential scanning calorimetry of chiral mixtures. Int J Pharm. 1992; 86:211-219.
  17. McKeown RH, Prankerd RJ. First Thermodynamic Dissociation Constants of Barbituric Acids in Water at 25°C. Part 3. 5,5-Alkylenebarbituric Acids. A Comparison with 5,5-Dialkylbarbituric Acids, and with Mono- and Di- Carboxylic Acids.  J Chem Soc (Perkin II). 1981; 481-7.