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Dr Philip E Thompson

Photo of Dr Thompson

Senior Lecturer

BSc(Hons) University of Melbourne
PhD University of Melbourne

Phone: +61 3 9903 9672
Fax: +61 3 9903 9582
Email: phil.thompson@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Structure-based design and synthesis of kinase and phosphodiesterase inhibitors
  • Peptides and Peptidomimetics

Education

  • Medicinal chemistry

Representative publications

  1. Kaiserman D, Buckle AM, Damme PV, Irving JA, Law RHP, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson PE, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI. The structure of granzyme C reveals an unusual mechanism of protease auto-inhibition. Proc Nat Acad Sci USA. Accepted 2009 2 17.
  2. Hanna-Elias A, Thompson PE, Manallack DT, Irving HR, Coupar IM, Berque-Bestel I, Iskander MN. The use of tripeptides for lead discovery of 5-HT4 receptor ligands. Peptide and Protein Letters. Accepted  2008 12 9.
  3. Vivian JP, Scoullar J,  Robertson AL, Bottomley SP, Horne J, Chin Y,  Wielens J, Thompson PE, Velkov T,  Piek S, Byres E,  Beddoe T, Wilce MCJ, Kahler J, Rossjohn J, Scanlon MJJ. Structural and biochemical characterisation of the oxidoreductase NmDsbA3 from Neisseria meningitides. Biol Chem. 2008; doi:10.1074/jbc.M803990200.
  4. Frazzetto M, Suphioglu C, Zhu J, Schmidt-Kittler O, Jennings IG, Cranmer SL, Jackson SP, Kinzler KW, Vogelstein B, Thompson PE. Dissecting Isoform Selectivity of PI3 Kinase Inhibitors. The Role of Non-conserved Residues in the Catalytic Pocket. Biochem J. 2008; 414: 383-390.
  5. Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE, Mulvey HT, Albiston AL. Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.  BMC Neuroscience. 2008; 9:S14. 
  6. Camerino MA, Chalmers DK, Thompson PE. Computer-assisted design of cyclic peptides and peptidomimetics. Chemistry Today (Chimica Oggi). 2008: 26:46-51.
  7. Camerino MA, Kong DCM, Chalmers DK, Thompson PE.  Solid Phase Synthesis and Circular Dichroism Analysis of (i→i+4) Cyclic Lactam Analogues of Kisspeptin. Int J Peptide Res Ther. 2008; 14:323-331.
  8. Thompson PE, Degerman E, Manganiello VC. Re-discovering PDE3 inhibitors – new opportunities for a long neglected target. Curr Topics Med Chem. 2007; 7:421-436.
  9. Kaiserman D, Bird CH, Sun J, Matthews A, Ung K, Whisstock JC, Thompson PE, Trapani JE, Bird PI. The Major Human and Mouse Granzymes are structurally and Functionally Divergent. J Cell Biology. 2006; 175:619-630.
  10. Abbott BM, Thompson PE. Analysis of anti- PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bio-org Med Chem Letters. 2006; 16:969-973.
  11. Jackson SP, Schoenwalder SM, Goncalves I, Nesbitt WS, Yap CL, Wright CE, Kenche V, Anderson KE, Dopheide SM, Yuan Y, Sturgeon SA, Prabaharan H, Thompson PE, Smith GD, Shepherd PR, Daniele N, Kulkarni S, Abbott B, Saylik D, Jones C, Lu L, Giuliano S, Hughan S, Angus JA, Robertson AD, Salem HH. PI 3-kinase p110β: a new target for antithrombotic therapy. Nature Medicine. 2005; 11:507-514.
  12. Manallack D, Hughes RA, Thompson PE. The next generation of phosphodiesterases – structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005; 48:3449-3462.
  13. Cranmer SL, Pikovski I,  Mangin P, Domagala T, Thompson PE, Frazzetto M, Salem HH, Jackson SP. Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Iba Biochem J. 2005; 387:849-858.
  14. Abbott B, Thompson PE. A reversed-phase HPLC-base method for the assay of cyclic nucleotide phosphodiesterase activity. Anal Biochem. 2005; 339:185-187.
  15. Abbott B, Thompson PE. PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. Bio-org Med Chem Letters. 2004; 14:2847-2851.
  16. Abbott B, Thompson PE. Synthetic Studies of LY294002: A Phosphatidylinositol 3-Kinase Inhibitor. Aust J Chem. 2003; 56:1109-1106.
  17. Schoenwalder SM, Hughan S, Boniface K, Fernando S, Holdworth M, Thompson PE, Jackson SP. Shear-dependent role for RhoA in regulating the adhesive function of platelet integrin aIIbb3. J Biol Chem. 2002; 277:14738-14746. 
  18. Sun J, Whisstock JC, Harriott P, Walker B, Novak A, Thompson PE, Smith AI, Bird PI. Importance of the P4' Residue in Human Granzyme B Inhibitors and Substrates Revealed by Scanning Mutagenesis of the PI-9 Reactive Center Loop. J Biol Chem. 2001; 276:15177-15184.
  19. Cavallaro V, Thompson P, Hearn M. Solid phase synthesis of cyclic analogues related to the hypoglycaemic peptides hGH (6-13): Comparison of two i®i+4 Lactam cyclisation procedures. J Peptide Sci. 2001; 7:529-536.
  20. Cavallaro V, Thompson P, Hearn M. Solid phase synthesis of a dendritic peptide related to a retinoblastoma protein fragment using a combined Boc- and Fmoc- approach. J Peptide Sci. 2001; 7:262-269.