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Dr Paul White

Image of Dr Paul White

Senior Lecturer
Alternate Associate Dean (Teaching)

BSc Monash University
PhD  Monash University
GCHE Monash University

Phone: +61 3 9903 9074
Fax:  +61 3 9903 9638
email: paul.white@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences

Research interests

  • Gene silencing, particularly using siRNA
  • Delivery of siRNA to the heart and blood vessels
  • Multi-functional nanoparticles for large-molecule drug delivery
  • Ischaemic cardiovascular disease
  • Adenosine-receptor mediated cardioprotection

Education

  • Alternate Associate Dean (Teaching)
  • 51 lectures per year
  • Unit Coordinator: PAC2182 - Basis of drug action II, Bachelor of Pharmacy

Representative publications

  1. Urmaliya V, Church JE, Coupar IM, Pouton CW, White, PJ. Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves co-operative activation of adenosine A2A and A2B receptors by endogenous adenosine. J. Cardiovasc. Pharmacol., in press (accepted 2009 Mar 6).
  2. White PJ, Anastasopoulos A, Pouton CW, Boyd BJ. Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides. Exp. Opinion Mol. Med., in press (accepted 2008 Dec 17)
  3. White PJ. Barriers to successful delivery of short interfering RNA after systemic administration. Clin Exp Pharmacol Physiol. 2008; 35:1371-1376.
  4. White PJ, Anastasopoulos F, Church JE, Kuo CY, Boyd BJ, Hickey PL, Tu LS, Burns P, Lew AM, Heath WR, Davey GM and Pouton CW. Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants. Vaccine. 2008; 26:6824-6831.
  5. Gregg A, Bottle SE, Devine SM, Figler H, Linden J, White PJ, Pouton CW, Urmaliya V, Scammells PJ, et al. Dual acting antioxidant A(1) adenosine receptor agonists. Bioorg Med Chem Lett. 2007.
  6. Nguyen TT, Cao N, Short JL, White PJ. Intravenous insulin-like growth factor-I receptor antisense treatment reduces angiotensin receptor expression and function in spontaneously hypertensive rats. J Pharmacol Exp Ther. 2006; 318:1171-7.
  7. Gray AC, Coupar IM, White PJ. Comparison of opioid receptor distributions in the rat central nervous system. Life Sci. 2006; 79:674-85.
  8. Gray AC, Coupar IM, White PJ. Comparison of opioid receptor distributions in the rat ileum. Life Sci. 2006; 78:1610-6.
  9. Cao N, Lau S, Nguyen TT, White PJ. Characterization of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious Sprague-Dawley rats. Clin Exp Pharmacol Physiol. 2006; 33:1190-5.
  10. Nguyen TT, White PJ. Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats. Br J Pharmacol. 2005; 146:935-41.
  11. Gray AC, White PJ, Coupar IM. Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum. Br J Pharmacol. 2005; 144:687-94.
  12. White PJ, Atley LM, Wraight CJ. Antisense oligonucleotide treatments for psoriasis. Expert Opin Biol Ther. 2004; 4:75-81.
  13. White PJ, Nguyen TT. Chronic caffeine treatment causes changes in cardiac adenosine receptor function in rats. Pharmacology. 2002 Jul; 65(3):129-35.
  14. White PJ, Gray AC, Fogarty RD, Sinclair RD, Thumiger SP, Werther GA, et al. C-5 propyne-modified oligonucleotides penetrate the epidermis in psoriatic and not normal human skin after topical application. J Invest Dermatol. 2002 Jun; 118(6):1003-7.
  15. Fogarty RD, McKean SC, White PJ, Atley LM, Werther GA, Wraight CJ. Sequence dependence of C5-propynyl-dU,dC-phosphorothioate oligonucleotide inhibition of the human IGF-I receptor: mRNA, protein, and cell growth. Antisense Nucleic Acid Drug Dev. 2002 Dec; 12(6):369-77.
  16. Wraight CJ, White PJ. Antisense oligonucleotides in cutaneous therapy. Pharmacol Ther. 2001 Apr; 90(1):89-104.
  17. Wraight CJ, White PJ, McKean SC, Fogarty RD, Venables DJ, Liepe IJ, et al. Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides. Nat Biotechnol. 2000 May; 18(5):521-6.
  18. White PJ, Fogarty RD, Liepe IJ, Delaney PM, Werther GA, Wraight CJ. Live confocal microscopy of oligonucleotide uptake by keratinocytes in human skin grafts on nude mice. J Invest Dermatol. 1999 Jun; 112(6):887-92.
  19. White PJ, Rose'Meyer RB, Hope W. Functional characterization of adenosine receptors in the nucleus tractus solitarius mediating hypotensive responses in the rat. Br J Pharmacol. 1996 Jan; 117(2):305-8.
  20. White PJ, Hope W, Rose'Meyer RB. The role of adenosine in the hypotensive actions of morphine. Eur J Pharmacol. 1995 Nov 24; 286(3):315-19.
  21. White PJ, Rose'Meyer RB, Hope W. Changes in adenosine receptors mediating hypotension in morphine-dependent rats. Eur J Pharmacol. 1995 Dec 27; 294(1):215-20.