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Associate Professor Ossama El-Kabbani

Image of Dr El-Kabbani

BSc(Hons) University of Alexandria (Egypt)
PhD University of Saskatchewan (Canada)

Telephone: +61 3 9903 9691
Fax: +61 3 9903 9582
Email: ossama.el-kabbani@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Protein X-ray crystallography
  • Protein/ligand and protein/protein docking
  • Structure-based drug design
  • Enzyme catalysis and mechanism
  • Identifying enzyme inhibitors by virtual screening

Education

  • Protein structure and function
  • Enzyme inhibitors
  • Drug discovery and development
  • Pharmaceutical biochemistry
  • Structural biology
  • Enzyme/ligand interaction

Representative publications

  1. Dhagat U, Endo S, Mamiya H, Hara A, El-Kabbani O. Structure of the G225P/G226P Mutant of Mouse 3(17)a-Hydroxysteroid Dehydrgenase (AKR1C21) Ternary Complex: Implications for the Binding of Inhibitor and Substrate. Acta Crystallographica. 2009; D65:257-265.
  2. Carbone V, Zhao HT, Chung R, Endo S, Hara A, El-Kabbani O.Correlation of Binding Constants and Molecular Modeling of Inhibitors in the Active Sites of Aldose Reductase and Aldehyde Reductase. Bioorganic and Medicinal Chemistry. 2009; 17:1244-1250.
  3. Carbone V, Chung R, Endo S, Hara A, El-Kabbani O. Structure of Aldehyde Reductase in Ternary Complex with Coenzyme and the Potent 20a-Hydroxysteroid Dehydrogenase Inhibitor 3,5-Dichlorosalicylic Acid: Implications for Inhibitor Binding and Selectivity. Archives of Biochemistry and Biophysics. 2008; 479:82-87.
  4. Dhagat U, Endo S, Sumii R, Hara A, El-Kabbani O. Selectivity Determinants of Inhibitor Binding to Human 20-aHydroxysteroid  Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid. Journal of Medicinal Chemistry. 2008;  51: 4844-4848.
  5. Carbone V, Hara A, El-Kabbani O.  Structural and Functional Features of Dimeric Dihydrodiol Dehydrogenase. Cellular and Molecular Life Sciences. 2008;  65: 1464-1474 .
  6. Zhao H-T, Hazemann I, Mitschler A, Carbone V, Joachimiak A, Ginell S, Podjarny A, El-Kabbani O.  An Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 Å Resolution: Implications for the Inhibition Mechanism. Journal of Medicinal Chemistry. 2008;  51: 1478-1481.
  7. Carbone V, Endo S, Sumii R, Chung RP-T, Matsunaga T, Hara A, El-Kabbani O. Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-Directed mutagenesis. Proteins: Structure, Function and Bioinformatics. 2008; 70: 176–187 .
  8. El-Kabbani O, Podjarny A. Selectivity Determinants of the Aldose Reductase and Aldehyde Reductase Inhibitor Binding Sites.  Cellular and Molecular Life Sciences. 2007; 64:1970-1978.
  9. Dhagat U, Carbone V, Chung RP-T, Matsunaga T, Endo S, Hara A, El-Kabbani O. A salicylic acid-Based analogue discovered from virtual screening as a potent inhibitor of human 20α-hydroxysteroid dehydrogenase. Medicinal Chemistry. 2007;  3: 546–550 .
  10. Fenalti G, Law RHP, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga P, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O,  Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC. GABA Production by Glutamic Acid Decarboxylase is Regulated by a Dynamic Catalytic Loop. Nature Structural and Molecular Biology. 2007; 14:280-286.
  11. Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O. Molecular Characterization of a Disease Associated Conformational Epitope on GAD65 Recognised by a Human Monoclonal Antibody b96.11 . Molecular Immunology. 2007; 44:1178-89.
  12. Darmanin C, Iwata T, Carper D, El-Kabbani O. Discovery of Potential Sorbitol Dehydrogenase Inhibitors from Virtual Screening.  Medicinal Chemistry. 2006; 2:239-242.
  13. Carbone V, Ishikura S, Hara A, El-Kabbani O. Structure-Based Discovery of Human L- Xylulose Reductase Inhibitors from Database Screening and Molecular Docking. Bioorganic and Medicinal Chemistry. 2005; 13:301-312.
  14. El-Kabbani O, Carbone V, Darmanin C, Ishikura S, Hara A. Structure of the Tetrameric form of Human L-Xylulose Reductase: Probing the Inhibitor-Binding Site with Molecular Modelling and Site-Directed Mutagenesis.  Proteins: Structure, Function and Bioinformatics. 2005; 60:424-432.
  15. El-Kabbani O, Carbone V, Darmanin C, Oka M, Mitschler A, Podjarny A, Schulze-Briese C, Chung RP-T. Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity.  Journal of Medicinal Chemistry. 2005; 48:5536-5542.
  16. El-Kabbani O, Ruiz F, Darmanin C, Chung RP-T.  Aldose Reductase Structures: Implications for Mechanism and Inhibition.  Cellular and Molecular Life Sciences. 2004; 61:750-762.
  17. El-Kabbani O, Darmanin C, Chung RP-T.  Sorbitol Dehydrogenase: Structure, Function and Ligand Design.  Current Medicinal Chemistry. 2004; 11:465-476.
  18. El-Kabbani O, Darmanin C, Oka M, Schulze-Briese C, Tomizaki T, Hazemann I, Mitschler A, Podjarny A.  High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction Between the Enzyme and a Cyclic Imide Type Inhibitor. Journal of Medicinal Chemistry. 2004; 47:4530-4537.
  19. El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A.  Ultra-High Resolution Drug Design II: Atomic Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Fidarestat and Minalrestat: Implications for the Binding of Cyclic Imide Inhibitors. Proteins: Structure, Function and Bioinformatics 2004; 55:805-813.
  20. El-Kabbani O, Ishikura S, Darmanin C, Carbone V, Chung RP-T, Usami N, Hara A. Crystal Structure of Human L-Xylulose Reductase Holoenzyme: Probing the Role of Asn107 with Site-Directed Mutagenesis.  Proteins: Structure, Function and Bioinformatics 55: 724-732, 2004.

External appointments

  • Bio21 Collaborative Crystallisation Centre - Management Committee Member and CI.
    For further details please refer to website http://www.csiro.au/c3/