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Dr Martin J Scanlon

Photo of Dr Martin Scanlon

Senior Lecturer

BSc University of Leeds (UK)
PhD University of Nottingham (UK)

Phone: +61 3 9903 9540
Fax: +61 3 9903 9582
Email: martin.scanlon@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Fragment-based drug design
  • Structure-based design of novel anti-microbial agents
  • Analysis of protein-ligand interactions
  • Protein structure determination and structural biology

Education

  • Spectrometric identification of small molecules
  • Drug-protein interactions

Representative publications

  1. Velkov T, Lim, ML, Horne J, Simpson JS, Porter CJ, Scanlon MJ. Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein. Mol Cell Biochem. 2009 Jan 22. [Epub ahead of print]. 
  2. Heras B, Shouldice SR, Totsika M, Scanlon MJ, Schembri MA, Martin JL. DSB proteins and bacterial pathogenicity. Nat Rev Microbiol. 2009;7:215-225.
  3. Vivian JP, Scoullar J, Robertson AL, Bottomley SP, Horne J, Chin Y, et.al. Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis. J Biol Chem. 2008; 283:32452-32461.
  4. Robertson AL, Horne J, Ellisdon AM, Thomas B, Scanlon MJ, Bottomley SP. The structural impact of a polyglutamine tract is location-dependent. Biophys J. 2008; 95:5922-5930.
  5. Roberts BP, Scanlon MJ, Krippner GY, Chalmers DK. The Dotted Cap Notation: A Concise Notation for Describing Variegated Dendrimers. New J Chem 2008; 32,:1543-1554.
  6. Headey SJ, Vom A, Simpson JS, Scanlon MJ. Backbone assignments of the 34 kDa ketopantoate reductase from E. coli. Biomol NMR Assignments. 2008; 2:93-96.
  7. Chuang S, Velkov T, Horne J, Porter CJ, Scanlon MJ. Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008; 51:3755-3764.
  8. Velkov T, Horne J, Laguerre A, Jones E, Scanlon MJ, and Peter CJ.Examination of the role of intestinal Fatty Acid-binding protein in drug absorption using a parallel artificial membrane permeability assay. Chem Biol. 2007; 14:453-465.
  9. Horne J, Scanlon MJ.  Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae. Biomol NMR Assignments 2007; 1:75-76.
  10. Horne J, d'Auvergne EJ, Coles M, Velkov T, Chin, Y, Charman WN, et.al. Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae--a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA. J Mol Biol. 2007; 371:703-716.
  11. Perry CS, Charman SA, Prankerd RJ, Chiu FC, Scanlon MJ, Chalmers D, et.al. The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins. J Pharm Sci. 2006; 95:146-158.
  12. Gibbs GM, Scanlon MJ, Swarbrick J, Curtis S, Gallant E, Dulhunty AF, et.al. The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. J Biol Chem. 2006; 281:4156-4163.
  13. Velkov T, Chuang S, Wielens J, Sakellaris H, Charman WN, Peter CJ et.al. The interaction of lipophilic drugs with intestinal fatty acid-binding protein. J Biol Chem. 2005; 280:17769-17776.
  14. Velkov T, Chuang S, Prankerd R, Sakellaris H, Peter CJ, Scanlon MJ. An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli. Protein Expr Purif. 2005; 44:23-31.
  15. Jennings CV, Rosengren KJ, Daly NL, Plan M, Stevens J, Scanlon MJ, et.al. Isolation, Solution Structure, and Insecticidal Activity of Kalata B2, a Circular Protein with a Twist: Do Mobius Strips Exist in Nature? Biochemistry. 2005; 44:851-860.