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Dr Krishna K Machavaram

Image of Dr Krishna K Machavaram

Coordinator drug metabolism, Centre for Drug Candidate Optimization

BPharm Kakatiya University (India)
MPharm Kakatiya University (India)
PhD Kakatiya University (India)

Telephone: +61 3 9903 9744
Fax: +61 3 9903 9052
Email: krishna.machavaram@pharm.monash.edu.au

Drug metabolism,Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences

Research interests

  • Drug metabolism, pharmacokinetics and lymphatic transport
  • Pre-clinical development of new drug candidates

Representative publications

  1. Kota J, Machavaram KK, McLennan DN, Edwards GA, Porter CJ, Charman SA. Relative role of the lymphatics and the blood in subcutaneous protein absorption: Influence of different injection sites. Drug Metab Dispos. 2007 Dec; 35(12):2211-7. Epub 2007 Sep 17.
  2. Machavaram KK, Gundu J, Yamsani MR. Effect of rifampicin and ketoconazole on the pharmacokinetics of ranitidine in healthy human volunteers: A possible role of P-glycoprotein. Drug Metabol Drug Interact. 2006; 22(1):47-65.
  3. Machavaram KK, Gundu J, Yamsani MR. Effect of various CYP3A and P-gp modulators on the biliary clearance of bromosulphaphthalein in rats. Pharmazie. 2004 Dec; 59(12):957-60.
  4. Jayasagar G, Kumar MK, Chandrasekhar K, Rajesh V, Rao YM. Effect of itraconazole on the pharmacokinetics of celecoxib in healthy human volunteers. Pharmazie. 2003 Nov; 58(11):840-1.
  5. Jayasagar G, Krishna KM, Chandrasekhar K, Madhusudan RY. Influence of rifampicin pretreatment on the pharmacokintics of celecoxib in healthy male volunteers. Drug Metabol Drug Interact. 2003; 19(4):287-95
  6. Kumar MK, Jayasagar G, Chandrasekhar K, Ashok T, Rao YM. Validated HPLC method for the determination of ranitidine in human serum and its application in a clinical pharmacokinetic study. Pharmazie. 2003 Apr; 58(4):284-5
  7. Jayasagar G, Kumar MK, Chandrasekhar K, Prasad PS, Rao YM. Validated HPLC method for the determination of celecoxib in human serum and its application in a clinical pharmacokinetic study. Pharmazie. 2002 Sep; 57(9):619-21
  8. Jayasagar G, Kumar MK, Chandrasekhar K, Madhusudan RC, Madhusudan RY. Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers. Drug Metabol Drug Interact. 2002; 19(1):41-8
  9. Krishna DR,Kishan V, Krishna MR. Microbial cultures as models to predict drug metabolism: studies with phenytoin. Indian J Pharm Sci. 1998; 60(5):290-293.

External appointments

  • Member, American Association of Pharmaceutical Scientists, Arlington,VA, USA