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Dr James Swarbrick

Photo of Dr Swarbrick

Lecturer

BSc(Hons) Durham University (UK)
PhD Newcastle University (UK)

Telephone: +61 9903 9543
Fax: +61 9903 9582
Email: james.swarbrick@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Macromolecular NMR spectroscopy.
  • Protein structure, function and dynamics by NMR.
  • Drug discovery in infectious diseases – Targeting the folate pathway enzymes.
  • Fragment based drug discovery approaches.
  • Computational approaches at the interface of med chemistry design and receptor structure.

Education

  • NMR spectroscopy second year
  • NMR spectroscopy third year
  • NMR spectroscopy honours. Protein NMR and advanced small molecule NMR.
  • Protein structure

Representative publications

  1. Swarbrick JD, Ashton TD. NMR studies of dextromethorphan in both isotropic and anisotropic states. Chirality. 2009 Feb 19. [Epub ahead of print]
  2. Swarbrick JD, Cubeddu L, Ball GE, Curmi PMG, Gooley AA, Williams KL,  Bridget C. NMR assignment of prespore specific antigen—a cell surface adhesion glycoprotein from Dictyostelium discoideum Mabbutt Accepted: 21 October 2008
  3. Swarbrick J, Iliades P, Simpson JS, Macreadie I. Folate biosynthesis - reappraisal of old and novel targets in the search for new antimicrobials. The Open Enzyme Inhibition Journal. 2008; 1:12-33.
  4. Mertens HD, Callaghan JM, Swarbrick JD, McConville MJ, Gooley PR. A high-resolution solution structure of a trypanosomatid FYVE domain. Protein Sci. 2007 Nov; 16(11):2552-9. Epub 2007 Sep 28.
  5. Swarbrick JD, Buyya S, Gunawardana D, Gayler KR, McLennan AG, Gooley PR. Structure and substrate-binding mechanism of human Ap4A hydrolase. J Biol Chem. 2005 Mar 4; 280(9):8471-81
  6. Swarbrick JD, Bashtannyk T, Dixon M, Pau RN, Davidson BE, Gooley PR. Backbone resonance assignment of the 2H, 13C, 15N labelled 32kDa central domain of Escherichia coli TyrR. J Biomol NMR. 2002 Apr; 22(4):381-2
  7. Fletcher JI, Swarbrick JD, Maksel D, Gayler KR, Gooley PR. The structure of Ap(4)A hydrolase complexed with ATP-MgF(x) reveals the basis of substrate binding. Structure. 2002 Feb; 10(2):205-13.
  8. Swarbrick JD, Bashtannyk T, Maksel D, Zhang XR, Blackburn GM, Gayler KR, et.al.The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L. J Mol Biol. 2000 Oct 6; 302(5):1165-77.