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Dr Jamie Simpson

Dr Simpson, Lecturer, Medicinal Chemistry

Lecturer

BSc(Hons)  University of Queensland
PhD University of Queensland
 
Phone: +61 9903 9636
Fax: +61 9903 9582
email: jamie.simpson@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Fragment-based drug discovery
  • Enzyme inhibition
  • Peptidomimetics and non-natural amino acids
  • Biosynthesis
  • Natural Products Chemistry

Education

  • VPS3011 - Synthetic Medicinal Chemistry (Unit coordinator)
  • VPS3022 - Chemical Technologies for the Pharmaceutical Sciences (Unit coordinator)
  • VCP3022 - Medicinal Chemistry III B
  • BMC4200 - Honours Chemical Biology and Natural Products Chemistry

Representative publications

  1. Headey SJ, Vom A, Simpson JS, Scanlon MJ. Backbone assignments of the 34 kDa ketopantoate reductase from E. coli. Biomol NMR Assign. 2008; 2(1):93-96.
  2. Swarbrick J, Iliades P, Simpson JS, Macreadie I. Folate biosynthesis - reappraisal of old and novel targets in the search for new antimicrobials. The Open Enzyme Inhibition Journal. 2008; 1:12-33.
  3. O’Connell JL, Simpson JS, Dumanski PG, Simpson GW, Easton CJ. Aromatic chlorination of w-phenylalkylamines and w-phenylalkylamides in carbon tetrachloride and a,a,a-trifluorotoluene. Org Biomol Chem. 2006; 4:2716–2723.
  4. Barratt BJ, Easton CJ, Henry DJ, Li IHW, Radom L, Simpson JS. Inhibition of Peptidylglycine a-Hydroxylating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals. J Am Chem Soc. 2004; 126(41):13306-13311.
  5. Simpson JS, Garson MJ. Biosynthetic Pathways to Isocyanides and Isothiocyanates; Precursor Incorporation Studies on Terpene Metabolites in the Tropical Marine Sponges Amphimedon terpenensis and Axinyssa n.sp. Org Biomol Chem. 2004; 2:949-956.
  6. Simpson JS, Brust A, Garson MJ. Biosynthetic Pathways to Dichloroimines in Marine Sponges: Precursor Incorporation Studies on Terpene Metabolites in the Tropical Marine Sponge Stylotella aurantium. Org Biomol Chem. 2004; 2:939-948.
  7. Garson MJ, Simpson JS. Marine Isocyanides and Related Natural Products – Structure, Biosynthesis and Ecology. Nat Prod Rep. 2004; 21:164-179.
  8. Easton CJ, Edwards A, McNabb SB, Merrett MC, O’Connell JL, Simpson GW, Simpson JS, Willis AC.Allylic Halogenation of Unsaturated Amino Acids. Org Biomol Chem. 2003; 1:2492–2498