Dr Joseph A Nicolazzo

Lecturer

BPharm Victorian College of Pharmacy
PhD Monash University

Telephone: +61 3 9903 9605
Fax: +61 3 9903 9583
Email: joseph.nicolazzo@pharm.monash.edu.au

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences

• Central nervous system (CNS) drug delivery and factors affecting drug permeability across the blood-brain barrier (BBB)
• The role of BBB transport proteins on drug disposition into the CNS
• The impact of Alzheimer’s disease and epilepsy on BBB integrity and drug transport processes
• Buccal mucosal delivery of CNS-active entities

Education

Unit co-ordinator, Bachelor of Pharmacy

• PAC2232 (Drug Delivery and Disposition)
• PAC3231 (Drug Delivery, Disposition and Dynamics)

Unit co-ordinator, Bachelor of Pharmaceutical Sciences

• VPS3081 (Biopharmaceutics)

Lecturer:

• Factors affecting oral drug absorption
• Pharmacokinetics
• Bioavailability
• Therapeutic drug monitoring

Representative publications

1. Lestari ML, Nicolazzo JA, Finnin BC. A novel flow through diffusion cell for assessing drug transport across the buccal mucosa in vitro. J Pharm Sci. In Press.
2. Nicolazzo JA, Mannila J. The buccal mucosa as a site for systemic delivery of peptides and proteins. In Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development, M. Morishita and K. Park (Eds.). Informa, New York. In Press.
3. Nicolazzo JA, Katneni K. Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2). Curr Top Med Chem. 2009; 9:130-147.
4. Nicolazzo JA, Finnin BC. In vivo and in vitro models for assessing drug absorption across the buccal mucosa. In Drug Absorption Studies - In Situ, In Vitro, and In Silico Models, C. Ehrhardt and K.-J. Kim (Eds.). Springer, New York. 2008; 89-111.
5. Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li Q-X, Charman SA, Nicolazzo JA, Wilkins S, Deleva K, Lynch T, Kok G, Ritchie CW, Tanzi RE, Cappai R, Masters CL, Barnham KJ, Bush AI. Rapid restoration of cognition in Alzheimer’s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Aβ. Neuron. 2008; 59:43-55.
6. Nicolazzo JA, Nguyen TT, Katneni K, Steuten JA,  Smith G, Jarrott B, Callaway JK, Charman SA. Pharmacokinetics and brain uptake of AM-36, a novel neuroprotective agent, following intravenous administration to rats. J Pharm Pharmacol. 2008; 60:171-178.
7. Nicolazzo JA, Charman SA, Charman WN. Methods to assess drug permeability across the blood-brain barrier. J Pharm Pharmacol. 2006; 58:281-293.
8. Nicolazzo JA, Reed BL, Finnin BC. Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide. J Control Rel. 2005; 105:240-248.
9. Nicolazzo JA, Reed BL, Finnin BC. Buccal penetration enhancers – How do they really work? J Control Rel. 2005; 105:1-15.
10. Nicolazzo JA, Morgan TM, Reed BL, Finnin BC. Synergistic enhancement of testosterone transdermal delivery. J Control Rel. 2005; 103:577-585.
11. Nicolazzo JA, Reed BL, Finnin BC. Enhanced buccal mucosal retention and reduced buccal permeability of estradiol in the presence of padimate O and Azone® – a mechanistic study. J Pharm Sci. 2005; 94:873-882.
12. Nicolazzo JA, Reed BL, Finnin BC. Modification of buccal drug delivery following pretreatment with skin penetration enhancers. J Pharm Sci. 2004; 93:2054-2063.
13. Nicolazzo JA, Reed BL, Finnin BC. Assessment of the effects of sodium dodecyl sulfate on the buccal permeability of caffeine and estradiol. J Pharm Sci. 2004; 93:431-440.
14. Nicolazzo J, Reed BL, Finnin BC. Dent J. The potential of the buccal mucosa as a site for systemic drug delivery. Res. 2003; 82(Sp Iss C): 101.
15. Nicolazzo JA, Reed BL, Finnin BC. The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa. J Pharm Sci. 2003; 92:2399-2410.

External appointments

• Editor, Australasian Pharmaceutical Science Association (APSA) newsletter