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Dr John Hale

Image of John Hale

Research Fellow

PhD University of Otago (New Zealand)
BSc(Hons) University of Otago (New Zealand)

Telephone: +61 3 9903 9183
Fax: +61 3 9903 9629
Email: john.hale@pharm.monash.edu.au

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences

Research interests

  • Discovery and development of novel antimicrobial agents
  • Mechanisms of action of antimicrobial peptides
  • Mechanisms of resistance to antibiotics
  • Bacterial communication

 Representative publications

  1. Jiang Z, Vasil AI, Hale J, Hancock RE, Vasil ML, Hodges RS.  Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides. Advances in Experimental Medicine and Biology. 2009; 611:561-2.
  2. Cheng JTJ, Hale JD, Elliott M, Hancock REW, Straus SK.  Studying the effect of membrance composition on the antimicrobial peptides aurein 2.2 and 2.3 from australian southern bell frogs.  Biophysical Journal. 2009; 96(2):552-65.
  3. Jian, Z, Kullberg BJ, van der Lee H, Vasis AI, Hale JD, Mant CT, Hancock REW, Vasil ML, Netea MG, Hodges RS.  Effects of hydrophobicity on the antifungal activity of α-helical antimicrobial peptides.  Chemical Biology and Drug Design. 2008; 72(6):483-495.
  4. Jiang Z, Vasil, AI, Hale J, Hancock RE, Vasil ML, Hodges RS.  Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.  Biopolymers. 2008; 90(3):369-83.
  5. Hale JD, Hancock RE.  The alternative mechanisms of action of cationic antimicrobial peptides on bacteria.  Expert Review of Anti-infective therapy.  2007; 5(6):951-0.
  6. Pan YL, Cheng JT, Hale J, Pan J, Hancock REW, Straus SK.  Characterisation of the structure and membrane interaction of the antimicrobial peptides aurein 2.2 and 2.3 from australian southern bell frogs.  Biophysical Journal. 2007; 15:92(8): 2854-64.

  7. Stewart-Ornstein J, Hitchcock AP, Hernandez Cruz D, Henklein P, Overhage J, Hilpert K, Hale JD, Hancock REW.  Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins.  Journal of Physical Chemistry. 2007; Jul 5; 111(26):7691-9.

  8. Hale JD, Ting Y-T, Jack RW, Tagg JR, Heng NCK.  Bacteriocin (mutacin) production by the Streptococcus mutans genome sequence reference strain UA 159; elucidation of the antimicrobial repertoire by genetic dissection.  Applied and Environmental Microbiology. 2005; 71(11):7613-7.

  9. Hale, JD, Heng NC, Jack RW, Tagg JR.  Identification of nlmTE, the locus encoding the ABC transport system required for export of nonlantibiotic mutacins in Streptococcus mutans.  Journal of Bacteriology. 2005; 187(14): 5036-9.

  10. Hale JD, Balakrishnan M, Tagg JR.  Studies of the genetic basis for mutacin N and it relationship to mutacin I.  2003 Proceedings of the XVth Lancefield International symposium on Streptococci and Streptococcal Diseases.  Indian Journal of Medical Research. 2004; 119:247-51.

External appointments

  • Member of the New Zealand Microbiological Society
  • Member of the Australian Society for Antimicrobials
  • Member of the American Society for Microbiology