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Dr Jalal Jazayeri

Image of Dr Jalal Jazayeri

Lecturer

MSc Birmingham University (UK)
PhD Limerick University (Ireland)
GCHE  Monash University

Telephone: +61 3 9903 9653
Fax: +61 3 9903 9638
Email: jalal.jazayeri@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Emerging targets of biological therapies for rheumatoid arthritis
  • Cytokines as therapeutic agents for inflammatory arthritis
  • Attenuated bacteria for delivery of DNA vaccines
  • Molecular mechanism of antibiotic resistance in the strain Pseudomonas aerogenesa

Education

Lecture in:

  • Physiology - cells and tissues
  • Biochemistry
  • Molecular biology
  • Inflammation
  • Emerging drugs
  • Rheumatoid
  • Cytokine biology
  • Bio-drugs

Representative Publications

  1. Kuo C-Y,  Sinha S,  Jazayeri JA, Pouton CW. A stably engineered, suicidal strain of Listeria monocytogenes delivers protein and/or DNA to fully-differentiated intestinal epithelial monolayers. Molecular Pharmaceutics. In press. 2009; DOI: 10.1021/mp800153u
  2. Upadhyay A, Sharma G, Kivivuori S, Raye W, Zabihi E, Carroll GJ, Jazayeri JA. Role of a leukaemia inhibitory factor (LIF) antagonist in LIF and Oncostatin M (OSM) induced MMP-1, MMP-3, and TIMP-1 expression by primary articular chondrocytes. Cytokine. 2009; in press.
  3. Carroll G, Breidahl W, Jazayeri J.  Confirmation of Two Major Polyarticular Osteoarthritis (POA) Phenotypes - differentiation on the basis of joint topography.Osteoarthritis and Cartilage. 2009; in press.
  4. Mozafari M, Pardakhy A, Azmari A, Omri A, Jazayeri J.  Role of Carrier Systems in Cancer Nanotherapy. Journal of Liposome Research. In press. 2009.
  5. Tarwadi, Jazayeri JA, Prankerd RJ, Pouton CW.  Preparation and in Vitro Evaluation of Novel Lipopeptide Transfection Agents for Efficient Gene Delivery. Bioconjugate Chemistry. 2008
  6. Jazayeri JA, Carroll GJ.  Fc-based cytokines – prospects for engineering superior therapeutics. BioDrugs. 2008; 22(1):1-26
  7. Jazayeri JA, De Weerd N, Raye W, Zabihi E, Santos L, Taylor DA, Carroll GJ. Generation of mutant leukemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF. J Immunological Methods. 2008; 323:1-10.
  8. Jazayeri JA, De Weerd N, Raye W, Kivivouri S, Zabihi E, Carroll GJ. In Vitro Evaluation of Leukaemia Inhibitory Factor Receptor Antagonists as Candidate Therapeutics for Inflammatory Arthritis.  Journal of Interferon and Cytokine Research. 2007; 27(4):1281-9.
  9. Jazayeri JA. Biochemical studies on sheep body louse Bovicola ovis (Schrank) (Phthiraptera: Trichodectidae): comparison of pyrethroid and organophosphate resistant and susceptible strains. Pesticide Biochemistry and Physiology. 2004; 80:1-11
  10. Giles KM, Daly JM, Beveridge DJ, Jazayeri JA, Leedman PJ. The 3'-UTR of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein (CP1). J Bio Chem. 2003; 278(5): 2937-2946
  11. Jazayeri JA, Pembroke JTP.  Molecular Cloning and expression of the Cellulomonas flavigena cell-associated amylase gene in E.coli. Biotechnology Letters. 2003; 15:219-222
  12. Yang HA, Sivasithamparam K, Jazayeri JA, Barton JE and O’Brien PA.  Association of Rhizoctonia strains with bare patch disease of wheat in Western Australia.  Plant Pathology. 2003; 43:878-884
  13. Balmer LA, Beverage DJ, Jazayeri JA, Holmes EM, Thomson AM, Walker CE, Leedman PJ. Identification of a novel AU-rich element in the 3'-untranslated region of EGF-receptor mRNA that is the target for regulated RNA-binding proteins. Molecular and Cellular Biology. 2001; 21:2070-2084
  14. Seth D, Shaw K, Jazayeri JA, Leedman PJ.  Complex transcriptional and post-transcriptional regulation of EGF-receptor expression by EGF and TGFa in human prostate cancer cells.  British Journal of Cancer. 1999; 80(5/6):657-669.
  15. McCulloch RK, Jazayeri JA, Leedman PJ. Regulation of EGF-receptor expression by EGF and TGFα in epidermoid cancer cells is cell-type specific.  International Journal of Biochemistry and Cell Biology. 1998; 30:1265-1278. 
  16. Jazayeri JA, Pembroke JTP.  Transformation of the coryneform Cellulomonas flavigena with plasmid DNA via electroporation.  Biotechnology Techniques. 1990; 4(2)
  17. Jazayeri JA, Pembroke JTP. Mutants of Cellulomonas flavigena with altered cell-associated amylase activity. Biotechnology Letters. 1989; 11(7)
  18. Pembroke JT, Jazayeri JA, McCarthy JF. Studies on the amylase activity of Cellulomonas flavigena.  Microbe. 1986; 86:143-145.