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Dr Ian T Crosby

Photo of Dr Crosby

Senior Lecturer

BSc(Hons) University of Melbourne
PhD University of Melbourne

Telephone: +61 3 9903 9536
Fax: +61 3 9903 9614
Email: ian.crosby@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Novel antiviral compounds
  • Serotonergic compounds as anti-obesity agents
  • Design, synthesis and biological evaluation of novel antipsychotics
  • New and more selective cancer chemotherapy
  • Novel analgesics

Education

Lecturer:

  • Fundamental organic chemistry
  • Fundamental medicinal chemistry
  • Chemistry and mode of action anti-infective agents
  • Chemistry and mode of action auntonomic nervous system acting agents

Representative publications

  1. Capuano B, Crosby IT, Lloyd EJ, Podloucka A,Taylor DA. Synthesis and Preliminary Pharmacological Evaluation of 4 ' -Arylalkyl Analogues of Clozapine. IV. The Effects of Aromaticity and Isosteric Replacement. Aust J Chem. 2008;61:930-040.
  2. Crosby IT, Rose ML, Collis MP, de Bruyn PJ. Keep PLC Robertson AD. Synthesis and antiviral evaluation of trimeric naphthoquinone analogues of conocurvone. Antiviral Agents. Aust J Chem. 2008;61:768-784.
  3. Capuano B, Crosby IT, Lloyd EJ, Neve JE Taylor AD. Aminimides as Potential CNS Acting Agents. III. Design, Synthesis and Receptor Binding of Aminimide Analogues of Dopamine, Serotonin, Morphine and Nicotine. Aust J Chem. 2008;61:422–431.
  4. Capuano B, Crosby IT, Forsyth CM, Lloyd EJ, Vom A, Yuriev E. 8-Chloro-5-(4-phenethyl-1-piperazinyl)pyrido[2,3-b][1,5]benzoxazepine. Acta Cryst. 2008;64:1865–1866.
  5. Manallack DT, Crosby IT, Khakham Y Capuano B. Platensimycin: A Promising Antimicrobial Targeting Fatty Acid Synthesis. Curr Med Chem. 2008;15:705-710.
  6. Crosby IT, Pietersz GA, Ripper JA. Synthesis of Succinimidoalkylbenzaldehyde Analogues: Potential Bifunctional Linkers for Bioconjugation. Aust J Chem. 2008;61:138-143.
  7. Capuano B, Crosby IT, Lloyd EJ, Neve JE, Taylor DA. Aminimides as Potential CNS Acting Agents. II. Design, Synthesis and Receptor Binding of 4 ' -Arylalkyl Aminimide Analogues of Clozapine as Prospective Novel Antipsychotics. Aust J Chem. 2008;61:5-10.
  8. Crosby I, Choi N, Deadman JJ, Issa W, Jones ED, Macfarlane K, et.al. Integrase inhibitors - 2. PCT Int Appl. 2007; WO20070430. 
  9. Capuano B, Crosby IT, Fallon GD, Forsyth CM, Lloyd EJ, Podloucka A, et.al. Geometric forms of 8-chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine-acetone-pentane (2/1/1). Acta Cryst. 2007; E63:4034. 
  10. Capuano B, Crosby IT, Lloyd EJ, Neve JE, Taylor DA. Aminimides as Potential CNS Acting Agents. I. Design, Synthesis, and Receptor Binding of 4 ' -Aryl Aminimide Analogues of Clozapine as Prospective Novel Antipsychotics. Aust J Chem. 2007;60:673-684. 
  11. Capuano B, Crosby IT, Lloyd EJ, Neve JE.  The first aminimide synthesis from benzoyl azide and pyridine. Aust J Chem. 2007;60:214-7. 
  12. Capuano B, Crosby IT, Forsyth CM, Lloyd EJ, Vom A, Yuriev E.5,5'-(Piperazine-1,4-diyl)bis(8-chloropyrido[2,3-b][1,5]benzoxazepine). Acta Cryst. 2006; E62:5434-5436.  
  13. Wielens J, Crosby IT, Chalmers DKJ. A Three Dimensional of the Human unodeficiency Virus Type 1 Integration Complex. Comput Aided Mol Des.  2005; 301-317. 
  14. Coates JAV, Jones ED, Cox S, Crosby IT,  Bourke DG, Jeynes TP. Preparation of naphtho[2,1-b]pyran-7,10-diones as Antiviral Agents. CT Int Appl. 2005; WO2005095376.
  15. Capuano B, Crosby IT, Egan SJ, Fallon GD, Lloyd EJ, Neve JE. 4-Chloro-N-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazinio]benzamidate dichloromethane solvate. Acta Cryst. 2005;E61:20-22.
  16. Capuano B, Crosby IT, Lloyd EJ, Podloucka A, Taylor DA.  Synthesis and Preliminary Pharmacological Evaluation of Novel Antipsychotics  for the Treatment of Schizophrenia. Drugs Fut. 2004; 29(Suppl. A): 343. 
  17. Capuano B, Crosby IT, Lloyd EJ, Podloucka A, Taylor DA. Synthesis and Preliminary Pharmacological Evaluation of 4' -Arylalkyl Analogues of Clozapine.  II. Effect of the Nature and Length of the Linker. Aust J Chem. 2003; 56:875-886.
  18. Capuano B, Crosby IT, Fallon GD, Lloyd EJ, Yuriev E, Egan SJ. 2-Methyl-4-(4-methylpierazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiaxepine methanol solvate hydrate. Acta Cryst. 2003; 59:1367-1369.
  19. Capuano B, Crosby IT, Lloyd EJ, Taylor DA. Synthesis and Preliminary Pharmacological Evaluation of 4' -Arylmethyl Analogues of Clozapine.  I. The Effect of Aromatic Substituents. Aust J Chem. 2002; 55:565-576.
  20. Capuano B, Crosby IT, Lloyd EJ. Schizophrenia: Genesis, Receptorology and Current Therapeutics. Curr Med Chem. 2002; 9:521-48