Skip to content | Change text size
 

Dr Ian P Holmes

Image of Dr Ian P Holmes

Senior Research Fellow
Medicinal Chemistry group leader, Cancer Therapeutics CRC

BSc University of Nottingham (UK)
PhD University of Nottingham (UK)

Telephone: +61 3 9903 9164
Email: ian.holmes@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Lead identification and optimisation of drug molecules
  • Pre-clinical development of new drug candidates

Representative publications

  1. Gaines S, Holmes IP, Martin SL, Watson SP. Preparation of biphenylpentanoic acid derivatives as matrix metalloproteinase inhibitors. PCT Int Appl. 2005; WO2005026120A1.
  2. Holmes I, Watson SP. Preparation of (hetero)aryl-substituted succinate derivatives as matrix metalloproteinase inhibitors. PCT Int Appl.  2005; WO2005016868A2.
  3. Holmes I, Watson SP. Preparation of N-arylglycine derivatives and related compounds as inhibitors of matrix metalloproteinase. PCT Int Appl. 2004; WO 2004113279A1.
  4. Gaines S, Holmes IP, Watson SP. Preparation of 5-aryl-3-hydroxypentanoates as matrix metalloproteinase inhibitors. PCT Int Appl. 2004; WO2004110974A1
  5. Willis MC, Brace GN, Findlay TJK, Holmes IP. 2-(2-Haloalkenyl)aryl halides as substrates for palladium-catalyzed tandem C-N bond formation: efficient synthesis of 1-substituted indoles. Advanced Synthesis & Catalysis. 2006; 348(7+8):851-856.
  6. Willis MC, Brace GN, Holmes IP. Palladium-catalyzed tandem alkenyl and aryl C-N bond formation: A cascade N-annulation route to 1-functionalized indoles. Angewandte Chemie, International Edition. 2005; 44(3):403-406.
  7. Brunel JM, Holmes IP. Chemically catalyzed asymmetric cyanohydrin syntheses. Angewandte Chemie, International Edition. 2004; 43(21):2752-2778.
  8. Norsikian S, Holmes I, LagasseF, Kagan HB. A one-pot esterification of chiral O-trimethylsilyl-cyanohydrins with retention of stereochemistry. Tetrahedron Letters. 2002; 43(33):5715-5717.
  9. Holmes IP, Kagan HB. The asymmetric addition of trimethylsilylcyanide to aldehydes catalysed by anionic chiral nucleophiles. Part 2. Tetrahedron Letters. 2000; 41(39):7457-7460.
  10. Holmes IP, Kagan HB. The asymmetric addition of trimethylsilylcyanide to aldehydes catalysed by anionic chiral nucleophiles. Part 1. Tetrahedron Letters. 2000; 41(39):7453-7456.