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Dr Gaik B Orbell

Image of Dr Gaik B Orbell

Research Fellow

BSc(Hons) Flinders University
PhD Flinders University

Telephone: +61 3 9903 9550
Fax: +61 3 9903 9143
Email: gaik.orbell@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • N-Demethylation of opiate and tropane alkaloids and other tertiary N-methyl amines
  • Synthesis of sulfur- and nitrogen-containing biologically active heterocycles
  • Substituent electronic effects on biological activity

Representative publications

  1. Kok G, Ashton TD, Scammells P. An improved process for the N-demethylation of opiate alkaloids using an iron(II) catalyst in acetate buffer. J Adv Synth. Catal. 2009; 351:283 – 286.
  2. Adlard PA., Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, et.al. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Ab. Neuron, 2008; 59(1):43-55.
  3. Kok GB, von Itzstein M. A new facile synthesis of C(4) nitrogen-containing derivatives of KDN2en and KDO2en. Synthesis. 1997; 7:769-772.
  4. Kok GB, Campbell M, Mickey B, von Itzstein M. Synthesis and biological evaluation of sulfur isosteres of the potent influenza virus sialidase inhibitors 4-amino-4-deoxy- and 4-deoxy-4-guanidino-Neu5Ac2en. J Chem Soc. Perkin Trans 1. 1996; 23:2811-2815.
  5. von Itzstein M, Dyason JC, Oliver SW, White HF, Wu WY, Kok GB, et.al. A Study of the Active Site of Influenza Virus Sialidase: An Approach to the Rational Design of Novel Anti-influenza Drugs J Med Chem. 1996; 39(2):388-91.
  6. von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin, B, et al. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature. 1993; 363(6428):418-23.
  7. McCullough RD, Kok GB, Lerstrup KA, Cowan DO. Tetratellurafulvalene. J Am Chem Soc. 1987; 109(13):4115-16.
  8. Adcock W, Kok GB. Transmission of polar substituent effects in saturated systems: synthesis and fluorine-19 NMR study of 3-substituted adamant-1-yl fluorides.  J Org Chem. 1987; 52(3):356-64.