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Dr Gerard P Moloney

Image of Dr Gerard P Moloney

Senior Research Fellow
Medicinal chemist, Cancer Therapeutics CRC

PhD University of Melbourne

Telephone: +61 3 9903 9165
Email: gerard.moloney@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Lead discovery and optimisation of novel drug candidates for the treatment of cancer.

Representative publications

  1. Pietersz GA., Mottram PL, van de Velde NC, Sardjono CT, Esparon S, Moloney G et.al.  Inhibition of destructive autoimmune arthritis in Fcg RIIa transgenic mice by small chemical entities. Immunology and Cell Biology. 2009; 87(1):3-12.
  2. Moloney GP, Angus JA, Robertson AD, Stoermer MJ, Robinson M, Wright CE et.al. Synthesis and Cannabinoid Activity of a variety of 2,3-substitutedf-1-benzothiophene derivatives and 2,3-substituted benzofuran derivatives: Novel Agonists for the CB1 receptor.  Aus J Chem. 2008; 61(7):484-499.
  3. Moloney GP, Angus JA, Robertson AD, Stoermer MJ, Robinson M, Wright CE et.al. Synthesis and cannabinoid activity of 1-substituted indole-3-oxadiazole derivatives. Novel agonists for the CB1 receptor.  Eur J Med Chem. 2009; 43(3):513-539.
  4. Moloney GP, Garavelas, A, Martin GR, Maxwell M, Glen RJ.  Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists of the 5-HT1B receptor.  Eur J Med Chem. 2004; 39(4):305-321.
  5. Hogarth PM, Pietersz GA, Moloney GP. Preparation of substituted vinylbenzene derivatives as Fc receptor modulating compounds.  , (Arthron Limited, Australia)., PCT Int. Appl., 2004, 81 pp.  Patent No. WO 2004058747, Kind. A1, Date. 20040715.
  6. Moloney GP, Martin GR, Glen RC.Synthesis and Serotonergic Activity of variously substituted (3-amido)phenylpiperazine derivatives and 1-benzo[b]thiophene-4-piperazine derivatives:  Novel antagonists for the vascular 5-HT1B Receptor.  Eur J Med Chem. 2004; 39:305-321.
  7. Moloney GP, Robertson AD. Therapeutic Molecules and Methods  Australian Provisional Patent Application No. PR1180/00.
  8. Moloney GP, Kelly DP, Mack P. Synthesis of Acridine Based DNA Bis-Intercalating Agents.  Molecules. 2001; 6(3):218-231.
  9. Moloney GP. N-(2-Ethylmorpholino)-3-bis-ketothiene. Molecules, 2000, 6, M198.
  10. Moloney GP. 1-(2-Ethylmorpholino)-5-benzyloxy-3-(1-naphthoyl)pyrrolopyridine. Molecules. 2000; 6:M197.
  11. Moloney GP, Martin GR, Glen RC.  Synthesis and Serotonergic Activity of 2-Oxadiazolyl-5-Substituted-N,N-dimethyltryptamines:  Novel Antagonists for the Vascular 5-HT1B-like Receptor. J Chem Soc Perkins Trans 1. 1999; 2725-2733.
  12. Moloney GP, Martin GR, Glen RC. Synthesis and Serotonergic activity of a series of 2-(N-benzyl)-carboxamido-5-substituted-N,N-dimethyltryptamine Derivatives as Novel Antagonists for the Vascular 5HT1B-like Receptor. J Chem Soc Perkins Trans 1. 1999; (19):2699-2711.
  13. Moloney GP, Martin GR, Glen, RC. Synthesis and Pharmacological Profile of a Series of 2,5-substituted-N,N-dimethyltryptamine Derivatives as Novel Antagonists for the Vascular 5-HT1B-like Receptor. J Chem Soc Perkins Trans 1. 1999; 2713-2723.
  14. Moloney GP, Martin GR, Glen RC. Synthesis and Pharmacological Profile of a Series of 2,5-substituted-N,N-dimethyltryptamine Derivatives as Novel Antagonists for the Vascular 5-HT1B-like Receptor. J Chem Soc Perkins Trans 1. 1999; 2713-2723.
  15. Moloney GP, Martin GR, Mathews N, Milne A, Hobbs H, Dodsworth S et.al. Synthesis and Serotonergic Activity of Substituted (N-Benzyl-2-amido)-5-substituted tryptamines: Novel antagonists for the vascular 5-HT1B/1D Receptor. J Med Chem. 1999; 42:2504-2526.
  16. Glen RC, Moloney GP. Analysis of 5-HT Receptors and the design of therapeutic Analogues, rational molecular design in drug discovery.   Alfred Benzon Symposium 42, pages 33-46, Ed t. Liljefors, F. S. Jorgenson and P. Krogsgaard-Larsen, Munksgaard. Copenhagen, Denmark.
  17. Moloney GP, Iskander MN, Craik DJ, Nero T. Synthesis, NMR studies and Computational Analysis of Oxazolidine derivatives of several b-Adrenoreceptor Antagonists.   J Chem Soc Perkins. 1998; 2:199-206
  18. Moloney GP, Iskander MN, Craik DJ. 1H NMR Spectroscopic Studies of the Stability of an Oxazolidine Condensation Product.  Mag Res Chem. 1997; 35:337-341.
  19. Moloney GP, Robertson AD, Martin GR, MacLennan S, Mathews N, Dodsworth S, et.al. A Novel Series of 2,5-Substituted Tryptamine Derivatives as Vascular 5HT1B/1D  Receptor Antagonists.  J Med Chem. 1997; 40(15):2347-2362.
  20. Moloney GP. N-Benzyl-3-(2-morpholine)ethoxy-1- benzofuran-2-carboxamide.  Molecules. 2000; 6:M199.