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Dr Francis Chiu

Image of Dr Francis Chiu

Bioanalysis team leader, Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences

BPharm University of Sydney
PhD University of Sydney

Telephone: +61 3 9903 9045
Fax: +61 3 9903 9052
Email: francis.chiu@pharm.monash.edu.au

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences

Research interests

  • Mechanism of drug action
  • Rational drug design
  • Drug discovery and lead optimisation in infectious disease
  • LC/MS applications in pharmaceutical research

Representative publications

  1. Evison BJ, Chiu F, Pezzoni G, Phillips DR, Cutts SM. Formaldehyde-activated pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublet. Mol Pharm.  2008 April 15; 74:184-194.
  2. Kgomotso T, Chiu F, Ng K. Genistein- and Daidzein 7-O-ß-D-Glucuronic Acid Retain the Ability to Inhibit Copper-Mediated Lipid Oxidation of Low Density Lipoprotein. Molecular Nutrition & Food Research. 2008; 52:1457-1466.
  3. Le K, Chiu F, Ng K. Identification and quantification of antioxidants in Fructus lycii. Food Chemistry. 2007; 105:353-363.
  4. Cao G, Ali F, Chiu F, Zavascki A, Nation R, Li J. Development and validation of a reverse-phase high-performance liquid chromatography assay for polymyxin B in human plasma. J Antimicrobial Chemotherapy. 2008; 62(5):1009-1014
  5. Zhou L, Alker A, Ruf A, Wang X, Chiu FC, Morizzi J, et.al. Characterisation of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277. Bioorg Med Chem Lett. 2008 Mar 1; 18(5):1555-8.
  6. Creek DJ, Charman WN, Chiu FC, Prankerd RJ, Dong Y, Vennerstrom JL, et.al. Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials. Antimicrob Agents Chemother. 2008 Apr; 52(4):1291-6.
  7. Tang Y, Dong Y, Wittlin S, Charman SA, Chollet J, Chiu FC, et.al. Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides. Bioorg Med Chem Lett. 2007 Mar 1; 17(5):1260-5.
  8. Creek DJ, Charman WN, Chiu FCK, Prankerd RJ, McCullough KJ, Dong Y, et.al. Iron mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials. J Pharm Sci. 2007; 96(11):2945-2956.
  9. Perry CS, Charman SA, Prankerd RJ, Chiu FCK, Dong Y, Vennerstrom JL, et.al. Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials. J Pharm Sci. 2006; 95:737-747, 2006.
  10. Charman SA, Perry CS, Chiu FCK, McIntosh KA, Charman WN. Alteration of the pharmacokinetics of a new chemical entity in the presence of a substituted cyclodextrin. J Pharm Sci. 2006; 95:256-267.
  11. Perry CS, Charman SA, Prankerd RJ, Chiu FC, Scanlon MJ, Chalmers D, et.al. The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins. J Pharm Sci. 2006; 95:146-158.
  12. Leveque NL, Charman WN, Chiu FC. Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 18; 830(2):314-21.
  13. Creek DJ, Chiu FCK, Prankerd RJ, Charman SA, Charman WN. Kinetics of iron-mediated artemisinin degradation: Effect of solvent composition and iron salt. J Pharm Sci. 2005; 94:1820-1829.
  14. Dong Y, Chollet J, Matile H, Charman SA, Chiu FCK, Charman WN, et.al. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides:charting a workable SAR using simple prototypes. J Med Chem. 2005; 48:4953-4961.
  15. Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, et.al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19; 430(7002):838-9.