Skip to content | Change text size
 

Dr Elizabeth Yuriev

Photo of Dr Yuriev

Senior Lecturer

BSc(Hons) Kharkov State University (Ukraine)
PhD Victoria University

Telephone: +61 3 9903 9611
Fax: +61 3 9903 9143
Email: elizabeth.yuriev@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Antibody recognition of carbohydrate and peptide ligands. Implications for xenotransplantation
  • The synthesis and molecular modelling of novel antipsychotic agents
  • Steric aspects of nucleic acids recognition phenomena
  • Fragment-based screening and drug discovery
  • Molecular modelling of peptides complexing with MHC molecules. Implications for vaccine development

Education

  • Year level coordinator, Bachelor of Pharmacy & Bachelor of Pharmaceutical Sciences
  • Unit coordinator, Bachelor of Pharmacy & Bachelor of Pharmaceutical Sciences
  • Lecturer in physical chemistry, physicochemical basis of pharmacy, computational chemistry

Representative publications

  1. Khairallah GN, Stewart MB, Yuriev E, Xu Y, Orbell JD, O'Hair RAJ. Gas Phase Supramolecular Cluster Ions of Deoxyguanosine Induced by Binding to (2,2’:6’2’’-terpyridine)-platinum(II) and (diethylenetriamine)-platinum(II). Dalton Transactions. 2009; 1542-8.
  2. Apostolopoulos V, Lazoura E, Yu M, Yuriev E, Ramsland PA. MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines. Human Vaccines. 2008; 4(6):400-409.
  3. Katsara M, Yuriev E, Deraos G, Matsoukas J,  Ramsland PA, Apostolopoulos V. Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2. Molecular Immunology, 2008; 45(13):3661-3670.
  4. Yuriev E, Sandrin MS, Ramsland PA. Antibody-Ligand Docking: Insights into Peptide-Carbohydrate Mimicry. Molecular Simulation. 2008; 34(4):461-468.
  5. Milland J, Yuriev E, Xing PX, McKenzie IFC, Ramsland PA, Sandrin MS. Carbohydrate Residues Downstream of the Terminal Gala(1,3)Gal Epitope Modulate the Specificity of Xenoreactive Antibodies. Immunology and Cell Biology. 2007; 85:623-632.
  6. Yuriev E, Farrugia W, Scott AM, Ramsland PA. Three-dimensional Structures of Carbohydrate Determinants of Lewis System Antigens: Implications for Effective Antibody Targeting of Cancer. Immunology and Cell Biology. 2005; 83(6):709-17.
  7. Yuriev E, Kong DC, Iskander MN. Investigation of Structure-Activity Relationships in a Series of Glibenclamide Analogues. European Journal of Medicinal Chemistry. 2004;39:835–847.
  8. Ramsland PA, Farrugia W, Yuriev E, Edmundson AB , Sandrin MS. Evidence for Structurally Conserved Recognition of the Major Carbohydrate Xenoantigen by Natural Antibodies. Cell Mol Biol (Noisy-le-grand). 2003; 49(2):307-17.
  9. Apostolopoulos V, Yuriev E, Ramsland PA, Halton J, Osinski C, Li W, et.al. A glycopeptide in Complex with MHC Class I Uses the GalNAc Residue as an Anchor. Proceedings of the National Academy of Sciences of the United States of America . 2003; 100:15029-15034.
  10. Yuriev E, Ramsland PA. Mcg Light Chain Dimer as a Model System for Ligand Design: A Docking Study. Journal of Molecular Recognition. 2002; 15(5):331-340.
  11. Yuriev E, Ramsland PA, Edmundson AB. Recognition of IgG-derived Peptides by a Human IgM with an Unusual Combining Site. Scandinavian Journal of Immunology. 2002;55(3):242-253.
  12. Ramsland PA, Yuriev E, Edmundson AB. Immunoglobulin Cross-Reactivity Examined by Library Screening, Crystallography and Docking Studies. Combinatorial Chemistry and High Throughput Screening. 2001;4(5):397-408.
  13. Edmundson AB, Tribbick G, Plompen S, Geysen HM, Yuriev E, Ramsland PA. Binding of Synthetic Peptides by a Human Monoclonal IgM with an Unusual Combining Site Structure. Journal of Molecular Recognition. 2001; 14(4):229-238.
  14. Yuriev E, Ramsland PA, Edmundson AB. Docking of Combinatorial Peptide Libraries into a Broadly Cross-reactive Human IgM. Journal of Molecular Recognition. 2001;14(3):172-184.
  15. Costas C, Yuriev E, Meyer KL, Guion TS, Hanna MM. RNA-Protein Crosslinking to AMP Residues at Internal Positions in RNA with a New Photocrosslinking ATP Analog. Nucleic Acids Research. 2000; 28:1849-1858.
  16. Yuriev E, Scott D, Hanna MM. Effects of 5-[S-(2,4-Dinitrophenyl)-thio]-2'-deoxyuridine Analog Incorporation on the Structure and Stability of DNA Hybrids: Implications for the Design of Nucleic Acid Probes. Journal of Molecular Recognition. 1999; 12:337-345.
  17. Hanna MM, Yuriev E, Zhang J, Riggs Dl. Probing the Environment of Nascent RNA in E. coli Transcription Elongation Complexes Utilizing a New Fluorescent Ribonucleotide Analog. Nucleic Acids Research. 1999; 27:1369-1375.
  18. Yuriev E, Orbell JD. Steric Aspects of the Binding of Monofunctional Platinum(II) Complexes to Sites on Nucleobases: Metal Complex "Flatness" as a Structural Element of Speciation. Inorganic Chemistry. 1998; 37:6269-6275.
  19. Yuriev E, Orbell JD. Steric Parameters for Metal Binding Sites on Nucleobases. Inorganic Chemistry. 1996; 35:7914-7915.
  20. Yuriev E, Orbell JD. Modelling Steric Effects in DNA-Binding Platinum(II)-Am(m)ine Complexes, Journal of Computer-Aided Molecular Design. 1996; 10:589-606.

External apppointments

  • MRACI
  • MACS
  • AMMA (Association of the Molecular Modellers of Australasia – the Asia/Pacific Chapter of the Molecular Graphics and Modelling Society) – member of the national  committee