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Dr Daniel Malone

Photo of Dr Malone

Lecturer

BPharm(Hons) Monash University
PhD Monash University

Telephone: +61 3 9903 9576
Fax: +61 3 9903 9638
Email: dan.malone@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Neurochemical and behavioural effects of cannabinoids
  • Preclinical evaluation of novel antidepressant, anxiolytic and antipsychotic compounds
  • Environmental inducers of psychosis and schizophrenia-like symptoms
  • Evaluation of the effect of cannabinoids on sensorimotor gating
  • Investigation of the effects of cannabinoids on sensorimotor gating in animals with environmentally-induced psychosis
  • Role of neuromolecular markers such as Fos and CREB in psychosis and depression

Education

  • Year level co-ordinator, Bachelor of Pharmacy third year
  • Lecturer: Bachelor of Pharmacy and Bachelor of Pharmaceutical Sciences: pharmacology, biochemistry and physiology.
  • Areas of teaching expertise include the pharmacology of antipsychotics, antidepressants, the biochemistry of lipids, sensory physiology and neurophysiology

Representative publications

  1. Malone DT, Jongejan D, Taylor DA. Cannabidiol reverses the reduction in social interaction produced by low dose Δ9-tetrahydrocannabinol in rats.  Pharmacology, Biochemistry and Behavior, 2009; 93: 91–96.
  2. Malone DT, Kearn CS, Chongue L, Mackie K, Taylor DA. Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats. Neuroscience, 2008; 152:265-272.
  3. Tokanovic S, Malone DT, Ventura S. Stimulation of epithelial CB1 receptors inhibits contractions of the rat prostate gland. British Journal of Pharmacology, 2007; 150:227-234.
  4. Long LE, Malone DT, Taylor DA. Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice. Neuropsychopharmacology, 2006; 31(4):795-803.
  5. Malone DT, Taylor DA. The effect of tetrahydrocannabinol on sensorimotor gating in socially isolated rats. Behavioral Brain Research, 2006; 166(1):101-9.
  6. Long LE, Malone DT, Taylor DA. The pharmacological actions of cannabidiol. Drugs of the Future, 2005; 30(7):747-753.
  7. Malone DT, Long LE, Taylor DA. The effect of SR 141716 and apomorphine on sensorimotor gating in Swiss mice. Pharmacology, Biochemistry and Behavior, 2004; 77(4): 839-845.
  8. Malone DT, Taylor DA. Involvement of somatodendritic 5-HT1A receptors in Δ9‑tetrahydrocannabinol-induced hypothermia in the rat. Pharmacology,Biochemistry & Behavior, 2001;69: 595-601.
  9. Malone DT, Taylor DA. Modulation by fluoxetine of striatal dopamine release following Δ9-tetrahydrocannabinol: a microdialysis study in conscious rats. British Journal of Pharmacology,  1999; 128: 21-26
  10. Malone DT, Taylor DA. Modulation of Δ9-tetrahydrocannabinol-induced hypothermia by fluoxetine in the rat. British Journal of Pharmacology, 1998; 124: 1419-1424.