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Dr David A V Morton

Image of Dr David A V Morton

Co-course Director, Bachelor of Pharmaceutical Science
Lecturer
Senior Lecturer

BSc(Hons) University of Bristol (UK)
PhD University of Bristol (UK)
MRSC (Member of the Royal Society of Chemistry)
CChem (Chartered Chemist)
CSci (Chartered Scientist)

Telephone: +61 3 9903 9523
Fax: +61 3 9903 9583
email: david.morton@pharm.monash.edu.au
 
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences

Research interests

  • Particle engineering in drug delivery
  • Control and study of surface properties of fine particles, and effects on behaviour and function in drug delivery
  • Pulmonary drug delivery systems: understanding innovating and improving formulation technology, and application to new medicines.
  • Controlling agglomerate structures in inhalation and dissolution delivery formats
  • Controlling multi-component particle formation processes during spray drying
  • Mechano-chemical bonding to coat fine particles

Education

  • Bachelor of Pharmaceutical Science course co-director
  • Bachelor of Pharmaceutical Science course 3rd year co-ordinator
  • Unit co-ordinator for PSC1041- Mathematics for pharmaceutical scientists, PSC1042 - Introduction to pharmaceutical science, VPS3052 - Industrial project
  • Current teaching focus on pharmaceutics, drug delivery, manufacturing and quality (44 lectures)

Representative publications

  1. Begat P, Morton DAV, Shu J, Kippax P, Staniforth JN, Proce R. The role of force control agents in high-dose dry powder inhaler formulations. Journal of Pharmaceutical Sciences. 2009. 98(8): 2770-2783.
  2. Qi A, Friend JR, Ye LY, Morton DAV, McIntosh MP, Spicca L. Miniature inhalation therapy platform using surface accoustic wave microfluidic atomization. Lab on a Chip. 2009. 9: 2184-2193.
  3. Morton DAV, Stewart PJ, Das SC, Lifran E, Vu L, Sleigh R, Hourigan J. Engineered lactose carrier particles: does altered microstructure give improved performance? Respiratory Drug Delivery 2009. Editors RN Dalby, PR Byron, J Peart, JD SUman, PM Young. Publisher: David Healthcare International, pp 333-336.
  4. Das SC, Morton DAV, VU L, Hourigan J, Stewart PJ. A novel ternary component for dry powder inhaler formulations. Respiratory Drug Delivery 2009. Editors RN Dalby, PR Byron, J Peart, JD Suman, PM Young. Publisher: David Healthcare International, pp 327-332.
  5. Andreou JG, Stewart PJ, Morton DAV. Short-term changes in drug agglomeration within interactive mixtures following blending. Int. J. Pharmaceutics. In press, available online 2009.
  6. P Begat, Morton DAV, Shur J, Kippax P, Staniforth JN, Price R.The role of force control agents in high-dose dry powder inhaler formulations. J Pharm Sci. In press, available online 2009.
  7. Morton DAV, McIntosh M, Sou T. Investigating Effects of Surface Modifications on a Mannitol Dry Powder Inhaler Plume by Laser Diffraction. Respiratory Drug Delivery 2008, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, P M Young, Publisher: Davis Healthcare International, p649.
  8. Morton DAV, Stewart PJ, Zhou TQ. Investigating the Flow Modification of Fine Lactose Carrier Particles. Respiratory Drug Delivery 2008, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, P M Young, Publisher: Davis Healthcare International, p655.
  9. Kararup H, Kippax P, Morton DAV. Investigation of Powder Dispersion from a Dry Powder Inhaler Using Laser Diffraction. Respiratory Drug Delivery 2008, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, P M Young, Publisher: Davis Healthcare International, p611.
  10. Kamlag Y, Morton DAV. Intelligent Formulation by Design: a Case Study for Systemic Delivery. Respiratory Drug Delivery 2006, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, Publisher: Davis Healthcare International.
  11. Begat P, Morton DAV, Staniforth JN, Price R. The Influence of Force Control Agents on the Adhesive-Cohesive Balance in Dry Powder Inhaler Formulations. KONA 2005; 23:109-121.
  12. Begat P, Morton DAV, Staniforth JN, Price R. The Cohesive-Adhesive Balances in Dry Powder Inhaler Formulations I: Direct Quantification by Atomic Force Microscope. Pharm. Res. 2004 Sep; 21(9):1591-1597.
  13. Begat P, Morton DAV, Staniforth JN, Price R The Cohesive-Adhesive Balances in Dry Powder Inhaler Formulations II: Influence on Fine Particle Delivery Characteristics. Pharm. Res. 2004 Oct; 21(10): 1826-1833.
  14. Tobyn M, Staniforth JN, Morton DAV, Harmer Q, Newton ME. Active and intelligent inhaler device development. Int. J. Pharm. 2004 Jun 11; 277(1-2): 31-37.
  15. Kamlagv Y, Morton DAV, Staniforth JN. Improvements in Spray-Drying Of a Cohesive Material for Pulmonary Delivery. Respiratory Drug Delivery 2004, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, P M Young, Publisher: Davis Healthcare International.
  16. Harmer Q, Morton DAV. Optimising Device and Formulation to Regenerate Primary Particle Distributions for Systemic Delivery. Respiratory Drug Delivery 2004, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, P M Young, Publisher: Davis Healthcare International.
  17. Begat P, Morton DAV, Price R, Staniforth JN.Investigation into the Cohesive-Adhesive Force Balance within a Dry Powder Inhaler Formulation. Respiratory Drug Delivery 2004, Editors R N Dalby, P R Byron, J Peart, J D Suman, S J Farr, P M Young, Publisher: Davis Healthcare International.
  18. Begat P, Green M, Morton DAV, Price R, Staniforth JN, Whittock A et.al. The study of Force Control Additives in creating High-Performance Dry Powder Inhaler Formulations. Proceedings of Respiratory Drug Delivery 8, 2002 Arizona, US.
  19. Hogarth G, Knox SAR, Lloyd BR, Macpherson KA, Morton DAV, Orpen AG. Reactivity of Bis(diphenylphosphino)methane at a Di-iron Centre:Thermally Induced Rearrangements of Dimetallacyclopentenone Complexes [Fe2(CO)5{m-s:h3-C(O)CRCR}(m-dppm)]. Inorg Chim Acta. 1996 Oct 15; 251(1-2):167-176.
  20. Knox SAR, Lloyd BR, Morton DAV, Orpen AG, Turner ML. Reactions of [Fe2(CO)6(m-CO)(m-dppm)] with Alkynes: Step-wise Synthesis of Tropone at a Dinuclear Metal Centre.  Polyhedron. 1995 Sep; 14(19):2723-2743. (Voted most significant paper in1995).
  21. Caroli C, Coulon N, Morton DAV, Williams MM. Theoretical and Experimental Investigations on the Leakage of Steam, Gas and Aerosols Through Narrow Cracks and Capillaries. FISA-95 Symposium - European Union Research on Severe Accidents 1995, Luxembourg.
  22. Morton DAV, Mitchell JP. Aerosol Penetration Through Capillaries and Leaks: Experimental Studies on the Influence of Pressure. J Aerosol Sci. 1995; 26:353-367.
  23. Knox SAR, Morton DAV, Orpen AG, Turner ML. Reactivity of Allene at Phosphine-Bridged Diiron Centers - X-Ray Crystal-Structures of [Fe2(Co)S(Mu-Sigma,Eta-3-C(O)C(Ch2)2)-(Mu-Dppm)] and [Fe2(Co)4(Mu-Eta-3,Eta-3'-(Ch2)2c2(Ch2)2)(Mu-Dppm)].Et2O. Inorg Chim Acta. 1994; 220(1-2):201-214.
  24. Morton DAV, Orpen AG. Structural Systematics. Part 4. Conformations of the Diphosphine Ligands in M2(m-Ph2PCH2PPh2) and  M(Ph2PCH2CH2PPh2) Complexes. J Chem Soc Dalton Trans. 1992; (4):641-653.

External appointments

  • Programme committee: Drug Delivery to the Lungs