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Dr Ben J Boyd

Photo of Dr Ben Boyd

Senior Lecturer
Group coordinator – Drug Delivery Sciences

BSc (Hons) University of Melbourne
PhD University of Melbourne

Phone: +61 3 9903 9112
Fax: +61 3 9903 9560
Email: ben.boyd@pharm.monash.edu.au

Group coordinator – Drug Delivery Sciences group

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences

Research interests

  • Colloidal aspects of lipid-based formulation design and assessment
  • Dendrimers as colloidal drug delivery systems
  • Lipid based liquid crystalline drug delivery systems
  • Non-lamellar dispersed liquid crystalline systems in drug delivery
  • Novel particulate carriers for siRNA and DNA delivery
  • Novel methods for characterization of materials for drug delivery systems

Education

Bachelor of Pharmaceutical Sciences

  • First year physical chemistry
  • Second year product development (including industry placements)
  • Third year product development

Representative publications

  1. Lee K, Nguyen TH, Hanley T, Boyd B. Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs. International Journal of Pharmaceutics. 2009. 365:190-199. 
  2. Fong WK, Hanley T, Boyd BJ. Stimuli Responsive Nanostructured Liquid Crystals Provide ‘On-demand’ Drug Delivery In Vitro and In Vivo. Journal of Controlled Release. Accepted 2009 Jan 19.
  3. Boyd BJ, Dong YD, Rades T. Non-lamellar Liquid Crystalline Nanostructured Particles – Advances in Materials and Structure Determination. Journal of Liposome Research. Accepted 2008 Dec 8 (used as Cover Issue).
  4. White OJ, Anastasopoulos F, Church JE, Boyd BJ, Hickey P, Tu LS, et.al. Generic construction of single component nanoparticles that elicit humoral and cellular immune responses without the need for adjuvants. Vaccine. 2008; 26:6824–6831.
  5. Lee KWY, Hanley T, Boyd BJ. Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs.International Journal of Pharmaceutics. 2009; 365:190-199.
  6. Dong AW, Pascual-Izarra C, Pas SJ, Hill AJ, Boyd CJ, Drummond CJ. Positron Annihilation Lifetime Spectroscopy (PALS) as a Characterization Technique for Nanostructured Self-Assembled Amphiphile Systems. J Phys Chem B. 2009; 113:84-89.
  7. Dong YD, Dong AW, Larson I, Rappolt M, Amenitsch H, Boyd BJ, et.al. Impurities in commercial phytantriol significantly alter its lyotropic liquid crystalline phase behaviour. Langmuir. 2008; 24:6998-7003.
  8. Kaminskas L, Boyd BJ, Karellas P, Krippner G, Lessene R, Kelly B, et.al. The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly-L-lysine dendrimers. Molecular Pharmaceutics. 2008; 5:449-463.
  9. Boyd BJ, Rizwan SB, Dong YD, Hook S, Rades T. Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions – hexosomes are not necessarily flat hexagonal prisms. Langmuir. 2007; 23:12461-12464.
  10. Kaminskas L, Boyd BJ, Karellas P, Henderson S, Giannis M, Krippner G, et.al. Impact of surface derivatisation of poly-L-lysine dendrimers with anionic arylsulphonate or succinate groups on intravenous pharmacokinetics and disposition. Molecular Pharmaceutics. 2007; 4:949-961.
  11. Boyd BJ, Khoo S-M, Whittaker DV, Davey G, Porter CJH. A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats. International Journal of Pharmaceutics. 2007; 340:52-60.
  12. Dong Y-D, Larson I, Hanley T, Boyd BJ. Bulk and Dispersed Aqueous Phase Behaviour of Phytantriol: Effect of Vitamin E Acetate and F127 Polymer on Liquid Crystal Nanostructure. Langmuir. 2006; 22:9512-9518.
  13. Ma J-G, Boyd BJ, Drummond CJ. Positional Isomers of Linear Sodium Dodecyl Benzene Sulphonate: Solubility, Self-Assembly and Air/Water Interfacial Activity. Langmuir. 2006; 22:8646-8654.
  14. Boyd BJ, Kaminskas L, Karellas P, Krippner G, Porter CJH. Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution and evidence for metabolism and bioresorption after intravenous administration to rats. Molecular Pharmaceutics. 2006; 3: 614-627.Rated “Must read” in Faculty of 1000 Biology http://www.f1000biology.com/article/id/1047370/evaluation
  15. Boyd BJ, Whittaker DV, Khoo S-M, Davey G. Hexosomes formed from glycerate surfactants - Formulation as a colloidal carrier for irinotecan. International Journal of Pharmaceutics. 2006; 318:154-162.
  16. Boyd BJ,  Khoo S-M, Whittaker DV, Davey G. Lyotropic Liquid Crystalline Phases Prepared From Glycerate-Based Surfactants – Phase Behaviour and Formulation as Sustained Release Drug Delivery Systems. International Journal of Pharmaceutics. 2006; 309:218-226.
  17. Kaukonen A, Boyd BJ, Porter CJH, Charman WN. Drug olubilisation behaviour during in vitro digestion of simple triglyceride lipid solution formulations. Pharmaceutical Research. 2004; 21:245-253. (Winner CRS-Capsugel Graduate/Postdoc Award for Innovative Aspect of Gastrointestinal Drug Absorption and Delivery)
  18. Kossena GA, Boyd BJ, Porter CJH, Charman WN. Separation and Characterization of the Colloidal Phases Produced on Digestion of Common Formulation Lipids and Assessment of Their Impact on the Apparent Solubility of Selected Poorly Water-Soluble Drugs. J Pharm Sci. 2003; 92:634-648.
  19. Boyd BJ. Characterisation of drug release from cubosomes using the pressure ultrafiltration method. International Journal of Pharmaceutics. 2003; 260:239-247.
  20. Boyd BJ, Porter CJH, Charman WN. Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water Soluble Drugs Solubilised in Model Lipid Digestion Products. Journal of Pharmaceutical Sciences, 2002; 92:1262-1271.
  21. Boyd BJ, Drummond CJ, Krodkiewska I, Grieser F. How Chain Length, Headgroup Polymerization, and Anomeric Configuration Govern the Thermotropic and Lyotropic Liquid Crystalline Phase Behaviour and the Air-Water Interfacial Adsorption of Glucose-Based Surfactants. Langmuir. 2000; 16:7359-7367

External appointments

  • Honorary lecturer, University of Otago, New Zealand
  • Vice President – Australian Chapter of the Controlled Release Society
  • Secretary, Colloid Division of the Royal Australian Chemical Institute
  • Member of Steering Committee for Nanotechnology Focus Group, American Association of Pharmaceutical Sciences
  • Editorial Board positions for Journal of Pharmacy and Pharmacology, and Journal of Liposome Research