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Dr Bim Graham

Image of Dr Bim Graham

Lecturer

BSc(Hons) Monash University
PhD Monash University
GCHE Monash University

Telephone: +61 3 9903 9706
Fax: +61 3 9903 9582
Email: bim.graham@pharm.monash.edu.au

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Luminescent probes for bio-imaging and bio-sensing applications
  • Functionalised nanoparticles for multi-modal in vivo imaging
  • Novel reagents and strategies for bioconjugation
  • siRNA bioconjugates for gene knockdown therapy
  • Metal complex bioconjugates for nucleic acid cleavage
  • Fluorogenic assays to aid drug discovery

Education

  • Basis of Drug Action I (unit coordinator and lecturer)
  • Synthetic Chemistry I (lab coordinator)
  • Synthetic Chemistry II (unit coordinator and lecturer)
  • Chemical Technologies for the Pharmaceutical Sciences (lecturer)

Representative publications

  1. Belousoff MJ, Ung P, Forsyth CM, Tor Y, Spiccia L, Graham B. New macrocyclic terbium(III) complex for use in RNA footprinting experiments. J Amer Chem Soc. 2009; 131:1106-1114.
  2. Belousoff MJ, Graham B, Spiccia L, Tor Y. Cleavage of RNA oligonucleotides by aminoglycosides. Org Biomol Chem. 2009; 3:30-33.
  3. Belousoff MJ, Gasser G, Graham B, Tor Y, Spiccia L. Binding of HIV-1 TAR mRNA to a peptide nucleic acid oligomer and its conjugates with metal ion-binding multidentate ligands. J Biol Inorg Chem. 2009; 14:287-300.
  4. Gasser G, Tjioe L, Graham B, Tor Y, Spiccia L, Belousoff MJ, et.al.  Synthesis, copper(II) complexation, 64Cu-labeling and bioconjugation of a new bis(2-pyridylmethyl) derivative of 1,4,7-triazacyclononane. Bioconjugate Chem. 2008; 19:719-730.
  5. Belousoff MJ, Graham B, Spiccia L. Copper(II) complexes of N-methylated derivatives of ortho- and meta-xylyl-bridged bis(1,4,7-triazacyclononane) ligands. Synthesis, X-ray structure and reactivity as artificial nucleases. Eur J Inorg Chem. 2008; 26:4133-4139.
  6. Belousoff MJ, TjioeL, Graham B, Spiccia L. Synthesis, X-ray crystal structures and phosphate ester cleavage properties of bis(2-pyridylmethyl)amine copper(II) complexes with guanidine pendant groups. Inorg Chem. 2008; 47:8641-8651.
  7. Graham B, Spiccia L, Hearn MTW.  Examination of the binding behaviour of proteins with immobilized copper(II) complexes of o-, m- and p-xylylene bridged bis(1,4,7-triazacyclononane) macrocycles. J Chromatogr. 2008; 1194(A):30-37.
  8. Belousoff MJ, Battle AR, Graham B, Spiccia L. Syntheses, structures and hydrolytic properties of copper(II) complexes of asymmetrically N-functionalised 1,4,7-triazacyclononane ligands. Polyhedron. 2007; 26:344-355.
  9. Belousoff MJ, Graham B, Moubaraki B, Murray KS, Spiccia L. Oxalato-bridged binuclear copper(II) complexes of  N-alkylated derivatives of 1,4,7-triazacyclononane: synthesis, x-ray crystal structures and magnetic properties. Eur J Inorg Chem. 2006; 23:4872-4878.
  10. Belousoff MJ, Duriska MB, Graham B, Batten SR, Moubaraki B, Murray KS, Spiccia L. Synthesis, structure, magnetism and phosphate ester cleavage properties of copper(II) complexes of N-substituted derivatives of 1,4,7-triazacyclononane. Inorg Chem. 2006; 45:3746-3755.
  11. Battle AR, Graham B, Spiccia L, Moubaraki B, Murray KS, Skelton BW, White AH. Structure and magnetic properties of polynuclear chloro- and hydroxo-bridged copper complexes formed by a tetramacrocyclic derivative of 1,4,7-triazacyclononane. Inorg Chim Acta. 2006; 359:289-297.
  12. Graham B, Spiccia L, Batten SR, Skelton BW, White AH. Polynuclear nickel(II) and copper(II) complexes of hexaazamacrocycles incorporating pairs of diethylenetriamine subunits separated by aromatic spacers. Inorg Chim Acta. 2005; 358:3983-3994.
  13. Graham B, Spiccia L, Skelton BW, White AH, Hockless DCR. Imidazole derivatives of binuclear copper(II) and nickel(II) complexes incorporating bis(1,4,7-triazacyclononan-1-yl) ligands. Inorg Chim Acta. 2005; 358:3974-3982.
  14. Gasser G, Bond AM, Graham B, Kosowski Z, Spiccia L. Synthesis of new metal complex-biomolecule hybrids as redox sensors for specific nucleobases. NSTI-Nanotech. 2005; 1:412-415.
  15. Claeys M, Graham B, Vasa G, Wanga W, Vermeylen R, Pashynska V, Cafmeyer J, Guyon P, Andreae MO, Artaxo P, Maenhaut W. Formation of secondary organic aerosols through photooxidation of isoprene. Science. 2004; 20:1173-1176.
  16. Christensen T, Hearn MTW, Spiccia L, Jiang W, Mooney JT, Graham B. Peptide purification by means of metal ion affinity chromatography. International Publication Number WO 03/042249 A2. 2003.
  17. Graham B, Hearn MTW, Spiccia L, Skelton BW, White AH. Amino acid binding to copper(II) in (1,4,7-triazacyclononane)(L-histidine)copper(II) hexafluorophosphate monohydrate. Aust J Chem. 2003; 56:1259-1261.
  18. Warden A, Graham B, Hearn MTW, Spiccia L. Synthesis of novel derivatives of 1,4,7-triazacyclononane. Org Lett. 2001; 3:2855-2858.
  19. Graham B, Hearn MTW, Junk PC, Kepert CM, Mabbs FE, Moubaraki B, Murray KS, Spiccia L. Syntheses, crystal structures, magnetic properties, and EPR spectra of tetranuclear copper(II) complexes featuring pairs of "roof-shaped" Cu2X2 dimers with hydroxide, methoxide and azide bridges. Inorg Chem. 2001; 40:1536-1543.