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Dr Ben Capuano

Photo of Dr Capuano

Co-course Director, Bachelor of Pharmaceutical Science
Lecturer

BAppSc (Chem) RMIT University
MPharm Victorian College of Pharmacy
PhD Monash University
 
Phone: +61 3 9903 9556
Fax: +61 3 9903 9582
Email: ben.capuano@pharm.monash.edu.au
 
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences

Research interests

  • Synthetic medicinal chemistry – small molecules
  • Drug discovery and lead identification in CNS disorders - schizophrenia and Parkinson’s disease
  • Drug discovery and lead identification of antibacterial agents based on colistin, platensimycin and inhibitors of KPR

Education

  • Co-course director: Bachelor of Pharmaceutical Science 
  • BPharmSc teaching:
    PSC1042 Introduction to pharmaceutical sciences
    VPS2021 Analytical methods
    VPS3091 Molecular basis of drug action
    VPS3082 Research project
  • BPharm teaching:
    PAC2171 Basis of drug action I
    VCP3021 Medicinal chemistry IIIA

Representative publications

  1. Capuano B, Crosby IT, Lloyd EJ, Podloucka A, Taylor DA. Synthesis and Preliminary Pharmacological Evaluation of 4'-Arylalkyl Analogues of Clozapine. IV. The Effects of Aromaticity and Isosteric Replacement. Aust J Chem. 2008; 61: 930–940.
  2. Capuano B, Crosby IT, Lloyd EJ, Neve JE, Taylor DA. Aminimides as Potential CNSActing Agents. III. Design, Synthesis and Receptor Binding of Aminimide Analogues of Dopamine, Serotonin, Morphine and Nicotine. Aust J Chem., 2008; 61:422–431.
  3. Capuano B, Crosby IT, Forsyth CM, Lloyd EJ, Vom A, Yuriev E. 8-Chloro-5-(4-phenethyl-1-piperazinyl)pyrido[2,3-b][1,5]benzoxazepine. Acta Cryst. 2008; 64:o1865–o1866.
  4. Capuano B, Hughes M, Prankherd R, Velkov T. A Protocol For The Combined Sub-Fractionation And Delipidation Of Lipid Binding Proteins Using Hydrophobic Interaction Chromatography. J Chrom B. 2008; 867:238-246.
  5. Manallack DT, Crosby IT, Khakham Y, Capuano B. Platensimycin: A Promising Antimicrobial Targeting Fatty Acid Synthesis. Curr Med Chem. 2008; 15:705-710. 
  6. Capuano B, Crosby IT, Lloyd EJ, Neve JE, Taylor DA. Aminimides as Potential CNS Acting Agents. II. Design, Synthesis and Receptor Binding of 4'-Arylalkyl Aminimide Analogues of Clozapine as Prospective Novel Antipsychotics. Aust J Chem. 2008; 61:5-10.
  7. Capuano B, Crosby IT, Lloyd EJ, Taylor DA. Synthesis and Preliminary Pharmacological Evaluation of 4' Arylalkyl Analogues of Clozapine. III. Replacement of the Tricyclic Nucleus with a Bicyclic Template. Aust J Chem. 2007; 60:928–933.
  8. Capuano B, Crosby IT, Lloyd EJ, Taylor DA. Aminimides as Potential CNS Acting Agents. I. Design, Synthesis and Receptor Binding of 4'-Aryl Aminimide Analogues of Clozapine as Putative Novel Antipsychotics. Aust J Chem. 2007; 60:673–684.
  9. Capuano B, Crosby IT, Fallon GD, Forsyth CM, Lloyd EJ, Podloucka A, et.al. Geometric forms of 8-chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine–acetone–pentane (2/1/1). Acta Cryst. 2007; 63(10):o4034.
  10. Capuano B, Crosby IT, Lloyd EJ, Neve JE. The First Aminimide Synthesis from Benzoyl Azide and Pyridine. Aust J Chem. 2007; 60:214-217.
  11. Capuano B, Crosby IT, Forsyth CM, Lloyd EJ, Vom A, Yuriev E. 5,5’-(Piperazine-1,4-diyl)bis(8-chloropyrido[2,3-b][1,5]benzoxazepine). Acta Cryst. 2006; 62:o5434-o5436.
  12. Capuano B, Crosby IT, Lim SEK, Lloyd EJ, Yuriev E. Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine. Molbank. 2006; M475:1-2.
  13. Camerino MA, Capuano B, Crosby IT, Lloyd EJ. Synthesis of benzyl 2-(4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazin-1-yl)acetate. Molbank. 2005; M453:1-2.
  14. Capuano B, Egan SJ, Fallon GD, Lloyd EJ, Neve JE. 4-Chloro-N-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazinio]benzamidate dichloromethane solvate. Acta Cryst. 2005 Jan; 61(1):20-o22.
  15. Capuano B, Crosby IT, Lloyd EJ, Taylor DA. Synthesis and Preliminary Pharmacological Evaluation of 4'-Arylalkyl Analogues of Clozapine.  II. Effect of the Nature and Length of the Linker. Aust J Chem. 2003; 56:875-886.
  16. Capuano B, Crosby IT, Fallon GD,Lloyd EJ, Yurieve E, Egan SJ. 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate monohydrate (olanzapine, ZyprexaTM). Acta Cryst. 2003; 56:o1367-o1369.
  17. Capuano B, Crosby IT, Lloyd EJ, Taylor DA.   Synthesis and Preliminary Pharmacological Evaluation of 4'‑Arylmethyl Analogues of Clozapine.  I. The Effect of Aromatic Substituents. Aust J Chem. 2002; 55(8):1-12.
  18. Capuano B, Crosby IT, Lloyd EJ. Schizophrenia: Genesis, Receptorology and Current Therapeutics. Curr Med Chem. 2002; 9 (5):521-548.
  19. Capuano B, Crosby IT, Gable RW, Lloyd EJ.  N-Piperonyl analogue of the atypical antipsychotic, clozapine. Acta Cryst. 2000; 56(3):339-340.
  20. Capuano B. 8-Chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazino]-5H-dibenzo[b,e][1,4]diazepine. Molecules. 1999; 4:329-332.

External appointments

  • Royal Australian Chemical Institute Pharmaceutical Sciences Group – Victorian Branch Acting Chair and Secretary