Honours Project Topics 2010

The Honours Degree of the Bachelor of Pharmaceutical Science (Projects based at the Clayton campus)

A

• A new approach to peptide synthesis - Associate Professor Patrick Perlmutter
• Alternate assay methods for pantothenate synthetase - Dr Kellie Tuck
• An approach to the total synthesis of norsecurinine using an aminohalogenation reaction - Dr David W. Lupton
• Approaches for the total synthesis of nortriterpenoid natural products within chinese herbal medicines - Dr David W. Lupton
• Asymmetric bond breaking: Beckwith-Dowd rearrangement - Dr David W. Lupton

B

• Bioconjugates for application in neuroscience - Alzheimer's Disease - Professor Leone Spiccia
• Biosensors and imaging agents based on metal complex bioconjugates - Professor Leone Spiccia
• Bismuth cluster compounds as new X-ray imaging agents - Professor Peter C. Junk, Associate Professor Phil Andrews and Professor Glen B. Deacon

• Bismuth NSAIDS as antimicrobial and slow release anti-inflammatory drugs - Associate Professor Phil Andrews, Professor Peter Junk and Dr Richard Ferrerro

 C

• Characterisation of PEGylated proteins and peptides - Professor Milton T. W. Hearn

D

• Design and synthesis of matrix metalloproteinase inhibitors - Professor Milton T. W. Hearn
• Development of chiral nitroxyl radicals as catalysts for enantioselective oxidations - Dr David W. Lupton
• Development of new antimony based anti-leishmania drugs - Associate Professor Phil Andrews, Professor Peter C. Junk and Dr Lukasz Kedzierski

E

• Exploiting new [3,3]-sigmatropic rearrangements - Associate Professor Patrick Perlmutter

H

• Hydrogen bond catalysis; fine tuning organic synthesis via the building blocks of life - Dr Christopher D. Thompson and Dr David W. Lupton

N

• Nano polymer micelles for drug delivery system - Dr Kei Saito and Dr Toby Bell
• Napththalene Diimide as a Sensor for Cations - Dr Sheshanath V. Bhosale and Professor Steven Langford
• New agents for the treatment of HIV - Professor Leone Spiccia
• Novel drug phases - Profesor Douglas MacFarlane and Dr Janet Scott

P

• Platinum anticancer drugs - Professor Glen B. Deacon, Professor Peter Junk and Professor Alan M. Bond
• Protein stabilisation in ionic liquids - Professor Douglas MacFarlane and Dr Janet Scott

S

• Synthesis and characterisation of biologically active bismuth sulphonates and phosphonates - Professor Peter C. Junk, Associate Professor Phil Andrews and Professor Glen B. Deacon
• Synthesis and characterisation of cyclic amide/imide-containing hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors - Professor Milton T. W. Hearn
• Synthesis of desferrioxamine analogues for treatment of iron toxicity - Professor Milton T. W Hearn
• Synthesis of imperanene derivatives as inhibitors of platelet aggregation - Professor Milton T. W. Hearn
• Synthesis of mitochondria-targeted pyruvate dehydrogenase kinase inhibitors as anti-cancer drugs - Professor Milton T. W. Hearn
• Synthesis of quinoline derivatives as therapeutic chelating agents for Alzheimer's disease - Professor Milton T. W. Hearn

T

• Total synthesis of pamamycin 607 - Associate Professor Patrick Perlmutter
• Total synthesis of Quercetin-3-rhamnoside and its heterocyclic analogues as neuraminidase inhibitors: A potential new class of anti influenza drug - Professor Milton T. W. Hearn
• Towards the synthesis of novel natural products - Dr Kellie Tuck

U

• Understanding adaptive immunity at a molecular level - Associate Professor Patrick Perlmutter
• Use of Naphthalene Diimide as an Anion Sensor - Dr Sheshanath V. Bhosale, Professor Steven Langford and Dr Kellie Tuck